新型含尿素化合物作为食欲素受体激动剂用于治疗睡眠障碍，即发作性睡病、发作性嗜睡症和睡眠呼吸暂停综合征。
Novel Urea-Containing Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, Namely, Narcolepsy, Hypersomnia, and Sleep Apnea Syndrome.
作者信息
Sabnis Ram W
机构信息
Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.
出版信息
ACS Med Chem Lett. 2025 Feb 18;16(3):375-376. doi: 10.1021/acsmedchemlett.5c00067. eCollection 2025 Mar 13.
Abstract
Provided herein are novel urea-containing compounds as orexin receptor agonists, pharmaceutical compositions, use of such compounds in treating sleep disorders, namely, narcolepsy, hypersomnia, and sleep apnea syndrome as well as processes for preparing such compounds.
摘要
本文提供了作为食欲素受体激动剂的新型含尿素化合物、药物组合物、此类化合物在治疗睡眠障碍即发作性睡病、发作性嗜睡症和睡眠呼吸暂停综合征中的用途以及制备此类化合物的方法。
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本文引用的文献
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The mechanism of different orexin/hypocretin neuronal projections in wakefulness and sleep.不同食欲素/下丘脑泌素神经元投射在清醒和睡眠中的机制。
Brain Res. 2025 Mar 1;1850:149408. doi: 10.1016/j.brainres.2024.149408. Epub 2024 Dec 19.
2
Novel Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, Namely, Narcolepsy and Hypersomnia.用于治疗睡眠障碍（即发作性睡病和发作性嗜睡症）的新型食欲素受体激动剂化合物。
ACS Med Chem Lett. 2024 Jul 3;15(8):1178-1179. doi: 10.1021/acsmedchemlett.4c00285. eCollection 2024 Aug 8.
3
Orexin increases the neuronal excitability of several brain areas associated with maintaining of arousal.食欲素增加了与维持觉醒相关的几个脑区的神经元兴奋性。
J Neurochem. 2024 Sep;168(9):2379-2390. doi: 10.1111/jnc.16195. Epub 2024 Aug 2.
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Narcolepsy and rapid eye movement sleep.发作性睡病与快速眼动睡眠
J Sleep Res. 2025 Apr;34(2):e14277. doi: 10.1111/jsr.14277. Epub 2024 Jul 2.
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Clinical usefulness of dual orexin receptor antagonism beyond insomnia: Neurological and psychiatric comorbidities.双重食欲素受体拮抗剂在失眠症之外的临床应用：神经和精神共病。
Neuropharmacology. 2024 Mar 1;245:109815. doi: 10.1016/j.neuropharm.2023.109815. Epub 2023 Dec 17.
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