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新型色胺化合物作为5-HT2A激动剂用于治疗情绪障碍，如抑郁症和双相情感障碍。

Novel Tryptamine Compounds as 5-HT2A Agonists for Treating Mood Disorders such as Depressive Disorders and Bipolar Disorders.

作者信息

Sabnis Ram W, Sabnis Anika R

机构信息

Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

出版信息

ACS Med Chem Lett. 2025 Feb 13;16(3):373-374. doi: 10.1021/acsmedchemlett.5c00047. eCollection 2025 Mar 13.

DOI:10.1021/acsmedchemlett.5c00047
PMID:40104784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11912261/
Abstract

Provided herein are novel tryptamine compounds as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating mood disorders such as depressive disorders and bipolar disorders and processes for preparing such compounds.

摘要

本文提供了作为5-HT2A激动剂的新型色胺化合物、药物组合物、此类化合物在治疗情绪障碍如抑郁症和双相情感障碍中的用途以及制备此类化合物的方法。