Hu Zenan, Yue Hanxun, Jiang Na, Qiao Liang
The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China.
Front Nutr. 2025 Mar 4;12:1539578. doi: 10.3389/fnut.2025.1539578. eCollection 2025.
Globally, metabolic dysfunction-associated fatty liver disease (MAFLD), also known as non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), is a common chronic liver disease. The progression of MAFLD leads to a vicious cycle in which oxidative stress results from the disease that is augmenting de-novo lipid levels and increases steatosis. Most non-enzymatic antioxidants are present in food. Therefore, the present review summarizes the findings of studies on food-derived antioxidants and presents an oxidative stress-related regulatory network in MAFLD, offering new ideas for MAFLD prevention and treatment.
在全球范围内，代谢功能障碍相关脂肪性肝病（MAFLD），也称为非酒精性脂肪性肝病（NAFLD）或代谢功能障碍相关脂肪性肝病（MASLD），是一种常见的慢性肝病。MAFLD的进展会导致恶性循环，即该疾病引发氧化应激，进而增加从头合成脂质水平并加剧脂肪变性。大多数非酶抗氧化剂存在于食物中。因此，本综述总结了关于食物来源抗氧化剂的研究结果，并提出了MAFLD中与氧化应激相关的调控网络，为MAFLD的预防和治疗提供了新思路。
