[急性白血病患儿营养成分的临床分析]
[Clinical analysis of nutritional components in children with acute leukemia].
作者信息
Shi Li-Xia, Zhao Ming-Zhong, Wang Fei-Fei, Xing Yu-Qian, Ji Hong-Yan, Zhao Ping
机构信息
Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan 250012, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2025 Mar 15;27(3):300-307. doi: 10.7499/j.issn.1008-8830.2408102.
OBJECTIVES
To assess the changes in body composition and nutritional risks faced by children with different stages of acute leukemia (AL).
METHODS
Bioelectrical impedance analysis combined with anthropometric measurements was used to detect body composition. This prospective study was conducted from August 2023 to July 2024 at Shandong Provincial Hospital, examining the body composition and physical balance of children with various stages of AL and healthy children.
RESULTS
The non-fat components of children with AL and healthy children both showed a linear increase with age. In the younger age group, there were no significant differences in body composition between children with AL and healthy children. However, in the older age group, the body composition of children undergoing chemotherapy for AL was significantly lower than that of healthy children (<0.05), and muscle mass recovered first after the completion of AL chemotherapy. The proportion of children with increased trunk fat in AL children who completed chemotherapy was significantly lower than that in healthy children (<0.05), while the incidence rate of severe left-right imbalance in body composition was significantly higher (<0.05). Muscle distribution in children with AL primarily showed insufficient limb and overall muscle mass, whereas healthy children mainly exhibited insufficient upper limb muscle mass.
CONCLUSIONS
The body composition of children with AL varies at different treatment stages, indicating that nutritional status is affected by both the disease itself and the treatment. Early screening can provide a basis for reasonable nutritional intervention.
目的
评估不同阶段急性白血病（AL）患儿的身体成分变化及面临的营养风险。
方法
采用生物电阻抗分析结合人体测量学方法检测身体成分。本前瞻性研究于2023年8月至2024年7月在山东省立医院进行，检测了不同阶段AL患儿及健康儿童的身体成分和身体平衡情况。
结果
AL患儿和健康儿童的非脂肪成分均随年龄呈线性增加。在较年幼的年龄组中，AL患儿与健康儿童的身体成分无显著差异。然而，在较年长的年龄组中，接受AL化疗的患儿身体成分显著低于健康儿童（<0.05），且肌肉量在AL化疗结束后最先恢复。完成化疗的AL患儿中躯干脂肪增加的比例显著低于健康儿童（<0.05），而身体成分严重左右失衡的发生率显著更高（<0.05）。AL患儿的肌肉分布主要表现为四肢和整体肌肉量不足，而健康儿童主要表现为上肢肌肉量不足。
结论
AL患儿在不同治疗阶段身体成分有所不同，表明营养状况受疾病本身及治疗的影响。早期筛查可为合理的营养干预提供依据。
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