铜酸盐离子对催化的双相体系中乙烯基砜的共轭硼氢化反应。
Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system.
作者信息
Jiang Siyu, Ge Yicen, Zhang Ai, Hu Silong, Jin Tao, Chen Jian, Zhang Huangfeng, Qin Yao, Ma Xiaoyan, Tang Jinghua, Liu Jinyu
机构信息
College of Materials, Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu, Sichuan 610059, China.
出版信息
Org Biomol Chem. 2025 Apr 2;23(14):3330-3335. doi: 10.1039/d5ob00242g.
Herein we report the conjugate borylation of vinyl sulfones mediated by ion pairing, which enables the efficient synthesis of β-sulfonyl alcohols bearing diverse functionalities in 13-98% yields. Further mechanistic investigations suggest the formation of anionic boryl-copper intermediates that kinetically accelerate reactant transfer across phases and provide enhanced boryl nucleophilicity.
在此，我们报道了离子对介导的乙烯基砜共轭硼氢化反应，该反应能够高效合成具有多种官能团的β-磺酰基醇，产率为13%-98%。进一步的机理研究表明，形成了阴离子硼基铜中间体，其在动力学上加速了反应物的跨相转移，并提供了增强的硼基亲核性。
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