Department of Pathophysiology, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Department of Conservative Dentistry and Endodontics, University of Cagliari, Cagliari, Italy.
J Endod. 2023 Nov;49(11):1421-1431. doi: 10.1016/j.joen.2023.07.024. Epub 2023 Aug 7.
This systematic review aimed to examine a potential link between apical periodontitis (AP) and gastrointestinal diseases (GIDs).
The protocol of the review has been registered in PROSPERO (CRD42022330771). The following engines were used with the aim of searching for relevant literature: PubMed, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and grey literature, from inception to May 2022. There were no language restrictions included. Study selection, data collection, and synthesis have been performed by 2 independent reviewers. For the purpose of estimating the quality of studies, the Newcastle-Ottawa Scale was used.
Four matched case control studies, as well as a single longitudinal cohort study were included in the final review. These were published between 2012 and 2017, and comprised 537 participants whose age range was 18 to 87 years. It was not possible to perform a meta-analysis due to different study designs and evaluated outcomes of included studies. Except for one study that was categorized as "Good," overall, for 4 out of 5 studies the quality was assessed as "Fair".
This review highlighted sparse knowledge present in the literature concerned with the association between AP and GIDs. Available evidence reveals a potential link between impaired endodontic status, assessed by the number of root-filled teeth with periapical radiolucency, and GIDs. More research is needed to ascertain this association.
本系统评价旨在研究根尖周炎（AP）与胃肠道疾病（GIDs）之间的潜在联系。
本综述的方案已在 PROSPERO（CRD42022330771）中注册。使用以下引擎搜索相关文献：PubMed、Web of Science、Scopus、Cochrane 对照试验中心注册库和灰色文献，从开始到 2022 年 5 月。未纳入任何语言限制。研究选择、数据收集和综合由 2 名独立审查员进行。为了评估研究的质量，使用了纽卡斯尔-渥太华量表。
最终综述纳入了 4 项匹配的病例对照研究和 1 项单纵向队列研究。这些研究发表于 2012 年至 2017 年之间，共有 537 名年龄在 18 至 87 岁之间的参与者。由于不同的研究设计和评估的研究结果，无法进行荟萃分析。除了一项被归类为“良好”的研究外，总体而言，5 项研究中有 4 项的质量被评估为“一般”。
本综述强调了文献中关于 AP 与 GIDs 之间关联的知识匮乏。现有证据表明，受损的牙髓状态（通过根尖周放射透影的根充牙数量评估）与 GIDs 之间存在潜在联系。需要更多的研究来确定这种关联。
