Hall Matt G, Cashmore Matt, Cho Hyo-Min, Ittermann Bernd, Keenan Kathryn E, Kolbitsch Christoph, Lee Changwoo, Li Chengwei, Ntata Asante, Obee Katie, Pu Zhang, Russek Stephen E, Stupic Karl F, Winter Lukas, Zilberti Luca, Steckner Michael
National Physical Laboratory, Teddington, UK.
Korea Research Institute of Standards and Science, Daejeon, Republic of Korea.
MAGMA. 2025 Mar 19. doi: 10.1007/s10334-025-01238-2.
Quantitative MRI has been an active area of research for decades and has produced a huge range of approaches with enormous potential for patient benefit. In many cases, however, there are challenges with reproducibility which have hampered clinical translation. Quantitative MRI is a form of measurement and like any other form of measurement it requires a supporting metrological framework to be fully consistent and compatible with the international system of units. This means not just expressing results in terms of seconds, meters, etc., but demonstrating consistency to their internationally recognized definitions. Such a framework for MRI is not yet complete, but a considerable amount of work has been done internationally towards building one. This article describes the current state of the art for MRI metrology, including a detailed description of metrological principles and how they are relevant to fully quantitative MRI. It also undertakes a gap analysis of where we are versus where we need to be to support reproducibility in MRI. It focusses particularly on the role and activities of national measurement institutes across the globe, illustrating the genuinely international and collaborative nature of the field.
几十年来，定量磁共振成像一直是一个活跃的研究领域，已经产生了大量的方法，具有为患者带来巨大益处的潜力。然而，在许多情况下，存在可重复性方面的挑战，这阻碍了临床转化。定量磁共振成像是一种测量形式，与任何其他测量形式一样，它需要一个支持性的计量框架，以完全符合并与国际单位制兼容。这不仅意味着要以秒、米等单位来表示结果，还意味着要证明其与国际公认定义的一致性。用于磁共振成像的这样一个框架尚未完善，但国际上已经开展了大量工作来构建它。本文描述了磁共振成像计量学的当前技术水平，包括对计量学原理及其与完全定量磁共振成像相关性的详细描述。它还对我们目前的状况与支持磁共振成像可重复性所需达到的状况进行了差距分析。它特别关注全球各国计量机构的作用和活动，展示了该领域真正的国际性和协作性。
