Bayraktaroğlu Serdar Bora, Turan Raife Dilek, Taşlı Neslihan Pakize, Şahin Fikrettin
Yeditepe Universitesi, Istanbul, Turkey.
Faculty of Engineering and Architecture, Department of Genetics and Bioengineering, Yeditepe University, Kayisdagi, Istanbul, Türkiye.
Methods Mol Biol. 2025;2960:85-93. doi: 10.1007/7651_2025_609.
The aging population is rapidly increasing, emphasizing the importance of understanding aging mechanisms and developing effective anti-aging therapies. This chapter investigates the efficacy of novel anti-aging agents, including exosomes and boron compounds, using the D-galactose-induced accelerated aging model. Both in vitro (skin organoid models) and in vivo (rat models) systems are employed to explore cellular, molecular, and histological changes. This comprehensive analysis provides critical insights into the potential of these agents in reversing age-associated pathologies.
老龄化人口正在迅速增加，这凸显了理解衰老机制和开发有效抗衰老疗法的重要性。本章使用D-半乳糖诱导的加速衰老模型研究新型抗衰老剂（包括外泌体和硼化合物）的功效。体外（皮肤类器官模型）和体内（大鼠模型）系统均被用于探索细胞、分子和组织学变化。这一全面分析为这些药物在逆转与年龄相关的病理状况方面的潜力提供了关键见解。
