MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research and State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Cells. 2022 Apr 22;11(9):1418. doi: 10.3390/cells11091418.
With the global increase of the elderly population, the improvement of the treatment for various aging-related diseases and the extension of a healthy lifespan have become some of the most important current medical issues. In order to understand the developmental mechanisms of aging and aging-related disorders, animal models are essential to conduct relevant studies. Among them, mice have become one of the most prevalently used model animals for aging-related studies due to their high similarity to humans in terms of genetic background and physiological structure, as well as their short lifespan and ease of reproduction. This review will discuss some of the common and emerging mouse models of accelerated aging and related chronic diseases in recent years, with the aim of serving as a reference for future application in fundamental and translational research.
随着全球老年人口的增加，各种与衰老相关疾病的治疗水平的提高以及健康寿命的延长已成为当前一些最重要的医学问题。为了了解衰老和与衰老相关的障碍的发展机制，动物模型对于开展相关研究至关重要。其中，由于遗传背景和生理结构与人类高度相似，以及寿命短、繁殖容易，因此小鼠已成为与衰老相关研究中最常用的模式动物之一。本文将讨论近年来一些常见和新兴的加速衰老和相关慢性疾病的小鼠模型，以期为未来在基础和转化研究中的应用提供参考。
Zotero 插件