Mahajan Nalini Kaul
Mother & Child Hospital, New Delhi, India.
Best Pract Res Clin Obstet Gynaecol. 2025 Mar;99:102591. doi: 10.1016/j.bpobgyn.2025.102591. Epub 2025 Mar 14.
Elective fertility preservation enables women to extend their reproductive window, potentially reducing the need for ineffective fertility treatments later in life. Oocyte cryopreservation (OC), an established fertility preservation technique, is often seen as a means of reproductive autonomy, though its impact remains debated. To avoid detrimental effects of aging it is suggested that OC should be done by 37 years. Freezing ≥20 mature oocytes before 38 years gives a 60-70°% possibility of pregnancy. Success of ovarian tissue cryopreservation and transplantation (OTCT) in cancer survivors has encouraged its use in reproductive aging. OTCT provides a longer reproductive window, allows for spontaneous conception and restores ovarian endocrine function but is highly invasive. Ethical concerns raised for elective fertility preservation include medicalization of reproduction, idealization of the right time for pregnancy, psychological effects of advanced age parenthood and promotion of social inequity. With an increasing demand for elective oocyte freezing there is an urgent need to create awareness about the pros and cons of the techniques, the risks of pregnancy complications at an advanced maternal age and long term health of children born. Gamete preservation cannot guarantee a child. Profertility counselling should be a part of the discussion as there is no substitute for spontaneous conception at a younger age.
选择性生育力保存使女性能够延长其生育窗口期,有可能减少日后对无效生育治疗的需求。卵母细胞冷冻保存(OC)是一种成熟的生育力保存技术,常被视为生殖自主权的一种方式,但其影响仍存在争议。为避免衰老的不利影响,建议在37岁之前进行OC。在38岁之前冷冻≥20个成熟卵母细胞,怀孕的可能性为60 - 70%。癌症幸存者中卵巢组织冷冻保存和移植(OTCT)的成功促使其在生殖衰老中得到应用。OTCT提供了更长的生育窗口期,允许自然受孕并恢复卵巢内分泌功能,但具有高度侵入性。选择性生育力保存引发的伦理问题包括生殖的医学化、怀孕最佳时机的理想化、高龄生育的心理影响以及社会不平等的加剧。随着对选择性卵母细胞冷冻的需求不断增加,迫切需要提高人们对这些技术的利弊、高龄产妇怀孕并发症风险以及所生孩子长期健康状况的认识。配子保存并不能保证生育一个孩子。生育咨询应该成为讨论的一部分,因为年轻时自然受孕是无可替代的。