基因组雪花：DNA折叠的独特性如何使我们感知化学世界。
Genomic snowflakes: how the uniqueness of DNA folding allows us to smell the chemical universe.
作者信息
Tan Longzhi, Xie X Sunney, Lomvardas Stavros
机构信息
Department of Neurobiology, Stanford University, Stanford, CA, USA. Electronic address: https://twitter.com/@tanlongzhi.
Biomedical Pioneering Innovation Center (BIOPIC), and School of Life Sciences, Peking University, Beijing, China; Department of Biochemistry and Molecular Biophysics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: https://twitter.com/@XieSunney.
出版信息
Curr Opin Genet Dev. 2025 Jun;92:102329. doi: 10.1016/j.gde.2025.102329. Epub 2025 Mar 18.
Olfactory receptor (OR) gene choice, the stable expression of one out of >2000 OR alleles by olfactory sensory neurons, constitutes a gene regulatory process that is driven by three-dimensional nuclear architecture. Moreover, the differentiation-dependent process that culminates in monogenic and monoallelic OR transcription represents a powerful demonstration of the rich mechanistic insight that single-cell genomics and multiomics can provide toward the understanding of a biological process. At this review, we describe the latest advances in the understanding of OR gene regulation and highlight important standing questions regarding the emerging specificity of ultra-long-range genomic interaction and the contribution of transcription and noncoding RNAs.
嗅觉受体（OR）基因选择，即嗅觉感觉神经元从2000多个OR等位基因中稳定表达一个，构成了一个由三维核结构驱动的基因调控过程。此外，以单基因和单等位基因OR转录为终点的依赖分化过程，有力地证明了单细胞基因组学和多组学在理解生物过程方面所能提供的丰富机制见解。在本综述中，我们描述了OR基因调控理解方面的最新进展，并强调了关于超长距离基因组相互作用新出现的特异性以及转录和非编码RNA的作用等重要悬而未决的问题。
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