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组胺2受体：治疗注意力缺陷多动障碍的新靶点。

Histamine 2 receptor: Emerging target for the treatment of attention-deficit/hyperactivity disorder.

作者信息

Shan Ling, Swaab Dick F

机构信息

Department Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.

Department Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.

出版信息

Cell Rep Med. 2025 Mar 18;6(3):102023. doi: 10.1016/j.xcrm.2025.102023.

DOI:10.1016/j.xcrm.2025.102023
PMID:40107248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11970375/
Abstract

A study by An et al. sheds a novel light on the potential role of histamine 2 receptor (HR) deficiency in attention-deficit/hyperactivity disorder (ADHD), which could be a future therapeutic target of ADHD. This spotlight provides an overview of the current knowledge of the histaminergic system and proposes future directions.

摘要

安等人的一项研究为组胺2受体（HR）缺乏在注意力缺陷多动障碍（ADHD）中的潜在作用带来了新的启示，这可能成为ADHD未来的治疗靶点。本综述概述了组胺能系统的现有知识，并提出了未来的研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35ca/11970375/6a1d70a7e817/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35ca/11970375/6a1d70a7e817/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35ca/11970375/6a1d70a7e817/gr1.jpg

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本文引用的文献

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Deficiency of histamine H receptors in parvalbumin-positive neurons leads to hyperactivity, impulsivity, and impaired attention.小白蛋白阳性神经元中组胺H受体的缺乏会导致多动、冲动和注意力受损。
Neuron. 2025 Feb 19;113(4):572-589.e6. doi: 10.1016/j.neuron.2024.12.002. Epub 2025 Jan 8.
2
Treatments in the pipeline for attention-deficit/hyperactivity disorder (ADHD) in adults.成人注意缺陷多动障碍（ADHD）的在研治疗方法。
Neurosci Biobehav Rev. 2024 Aug;163:105774. doi: 10.1016/j.neubiorev.2024.105774. Epub 2024 Jun 22.
3
Treatment Outcomes With Licensed and Unlicensed Stimulant Doses for Adults With Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.
治疗注意力缺陷/多动障碍成人的许可和未许可兴奋剂剂量的治疗结果：系统评价和荟萃分析。
JAMA Psychiatry. 2024 Feb 1;81(2):157-166. doi: 10.1001/jamapsychiatry.2023.3985.
4
ADHD in school-age children is related to infant exposure to systemic H1-antihistamines.学龄儿童的注意力缺陷多动障碍与婴儿期全身性H1抗组胺药暴露有关。
Allergy. 2020 Nov;75(11):2956-2957. doi: 10.1111/all.14411. Epub 2020 Jun 12.
5
Increased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use.特应性皮炎患者注意力缺陷/多动症状增加与抗组胺药物使用史有关。
Allergy. 2018 Mar;73(3):615-626. doi: 10.1111/all.13326. Epub 2017 Nov 20.
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International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.国际基础与临床药理学联合会。XCVIII.组胺受体。
Pharmacol Rev. 2015 Jul;67(3):601-55. doi: 10.1124/pr.114.010249.
7
Connectomic disturbances in attention-deficit/hyperactivity disorder: a whole-brain tractography analysis.注意缺陷多动障碍中的连接组学紊乱：全脑束路追踪分析。
Biol Psychiatry. 2014 Oct 15;76(8):656-63. doi: 10.1016/j.biopsych.2013.12.013. Epub 2014 Jan 8.
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Gender differences among children with ADHD on continuous performance tests: a meta-analytic review.儿童注意缺陷多动障碍患者在连续操作测试中的性别差异：一项荟萃分析综述。
J Atten Disord. 2012 Apr;16(3):190-8. doi: 10.1177/1087054711427398. Epub 2012 Jan 30.
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The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms.组氨酸降解基因多态性在调节食品添加剂对儿童注意缺陷多动障碍症状影响中的作用。
Am J Psychiatry. 2010 Sep;167(9):1108-15. doi: 10.1176/appi.ajp.2010.09101529. Epub 2010 Jun 15.
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