Horton Katie, Wing Peter A C, Jackson Claire L, McCormick Christopher J, Carroll Mary P, Lucas Jane S
School of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK.
Primary Ciliary Dyskinesia Centre, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Eur Respir Rev. 2025 Mar 19;34(175). doi: 10.1183/16000617.0224-2024. Print 2025 Jan.
The airway epithelium is the first point of contact for inhaled pathogens. The role of epithelial cells in clearance, infection and colonisation of bacteria is established. The interactions of respiratory viruses and cilia is less understood, but viruses are known to target ciliated epithelial cells for entry, replication and dissemination. Furthermore, some respiratory viruses impair and/or enhance ciliary activity. This review examines what is known about the interactions between cilia and viral infection and how respiratory viruses effect cilia function with subsequent consequences for human health. We discuss the models which can be used to investigate the relationship between respiratory viruses and the host airway.
气道上皮是吸入病原体的首个接触点。上皮细胞在细菌清除、感染和定植中的作用已得到证实。呼吸道病毒与纤毛之间的相互作用了解较少，但已知病毒以纤毛上皮细胞为靶点进行进入、复制和传播。此外，一些呼吸道病毒会损害和/或增强纤毛活性。本综述探讨了关于纤毛与病毒感染之间相互作用的已知情况，以及呼吸道病毒如何影响纤毛功能及其对人类健康的后续影响。我们讨论了可用于研究呼吸道病毒与宿主气道之间关系的模型。
