Soares-Marangoni Daniele Almeida, Arguelho Amanda de Oliveira, Mendonça Ayrles Silva Gonçalves Barbosa, Wiesiolek Carine Carolina, de Lima-Alvarez Carolina Daniel, Dos Chiquetti Eloá Maria, de Oliveira Everton Falcão, de Medeiros Márcio José, Pereira Silvana Alves, Hasue Renata Hydee
Graduate Program in Movement Sciences, Institute of Health, Federal University of Mato, Grosso do Sul, Campo Grande, MS, Brazil.
Graduate Program in Health and Development, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
BMC Pediatr. 2025 Mar 19;25(1):217. doi: 10.1186/s12887-025-05548-1.
The acronym STORCH encompasses gestational infections that can lead to congenital syndromes or adverse neurological outcomes in children. In Brazil and worldwide, there has been an alarming increase in confirmed cases of STORCH in recent years. However, no study has examined the impact of STORCH on infants' neurodevelopmental outcomes in a large, multi-center cohort, recruiting a substantial number of participants, with analysis across a broad set of variables and ages and based on the International Classification of Functioning, Disability and Health (ICF) model.
To examine the association between the exposure to classic STORCH (syphilis, toxoplasmosis, rubella, cytomegalovirus infection, and herpes simplex) on components of functioning in infants from 3 to 24 months old in Brazil.
We propose a multi-center prospective cohort study that includes data collection in at least one city from each geographical region of Brazil. A proposed total sample size of 296 infants will be included at 3 months (12-15 weeks post term). They will be equitably divided into: (a) an exposed group (n = 148), consisting of those diagnosed with any congenital STORCH infection or whose mothers experienced prenatal STORCH infection; (b) an unexposed group (n = 148). Assessments are carried out longitudinally at 3, 6, 9, 12, 18, and 24 months of age. Assessment tools include Prechtl's General Movements Assessment, Hammersmith Infant Neurological Examination, Alberta Infant Motor Scale; Bayley Scales of Infant and Toddler Development; Survey of Well-being of Young Children; Autism Observational Scale for Infants; Modified Checklist for Autism in Toddlers; Child Behavior Checklist; and Young Children's Participation and Environment Measure. Descriptive analyses, including the calculation of relative risk, and logistic regressions will be conducted to examine the association between gestational exposure to STORCH agents and infants' responses/outcomes.
The STORCH Brazil study will investigate the impact of STORCH exposure on functioning, including neurodevelopmental trajectories, in infants during their first two years, aligning with the ICF framework. This will enhance understanding of the characteristics and needs of STORCH-exposed infants, aiding therapists in making informed clinical decisions. The results might support public policies tailored to this population. Findings will be disseminated to ensure knowledge translation.
Not applicable.
首字母缩写词STORCH涵盖了可导致儿童先天性综合征或不良神经学结局的妊娠期感染。近年来，在巴西乃至全球，确诊的STORCH病例数均出现了惊人的增长。然而，尚无研究在大规模、多中心队列中，纳入大量参与者，基于广泛的变量和年龄范围，并依据国际功能、残疾和健康分类（ICF）模型，考察STORCH对婴儿神经发育结局的影响。
考察巴西3至24个月大婴儿接触经典STORCH（梅毒、弓形虫病、风疹、巨细胞病毒感染和单纯疱疹）与功能组成部分之间的关联。
我们提议开展一项多中心前瞻性队列研究，在巴西每个地理区域的至少一个城市收集数据。拟纳入296名3个月大（足月后12 - 15周）的婴儿作为总样本。他们将被公平地分为：（a）暴露组（n = 148），包括那些被诊断患有任何先天性STORCH感染或其母亲在孕期经历过STORCH感染的婴儿；（b）非暴露组（n = 148）。在3、6、9、12、18和24个月龄时进行纵向评估。评估工具包括普雷茨尔全身运动评估、哈默史密斯婴儿神经学检查、艾伯塔婴儿运动量表、贝利婴幼儿发展量表、幼儿幸福感调查、婴儿孤独症观察量表、幼儿孤独症改良检查表、儿童行为检查表以及幼儿参与和环境测量。将进行描述性分析，包括相对风险的计算，并进行逻辑回归分析，以考察孕期接触STORCH病原体与婴儿反应/结局之间的关联。
巴西STORCH研究将依据ICF框架，调查STORCH暴露对婴儿出生后头两年功能的影响，包括神经发育轨迹。这将增进对STORCH暴露婴儿特征和需求的理解，有助于治疗师做出明智的临床决策。研究结果可能会支持针对该人群制定的公共政策，并将研究结果进行传播以确保知识转化。
不适用。
