Potter E K, Reid I A
Neuroendocrinology. 1985 Jun;40(6):493-6. doi: 10.1159/000124120.
The effect of intravertebral infusion of angiotensin II on cardiac vagal efferent activity was studied in anesthetized mongrel dogs. Unilateral infusion of doses of angiotensin II as low as 5 ng/kg/min inhibited basal vagal tone and also decreased the slope of the relationship between cardiac vagal efferent activity and systolic blood pressure. Intravenous and intracarotid infusion of similar doses of angiotensin II produced little or no inhibition of vagal tone. These results demonstrate directly that angiotensin II can act centrally to inhibit cardiac vagal efferent activity and provide additional evidence that the increase in blood pressure produced by intravertebral angiotensin II results, at least in part, from decreased vagal tone to the heart.
在麻醉的杂种犬中研究了椎体内输注血管紧张素II对心脏迷走神经传出活动的影响。单侧输注低至5 ng/kg/min剂量的血管紧张素II可抑制基础迷走神经张力，并降低心脏迷走神经传出活动与收缩压之间关系的斜率。静脉内和颈内输注相似剂量的血管紧张素II对迷走神经张力几乎没有抑制作用或没有抑制作用。这些结果直接表明血管紧张素II可在中枢起作用以抑制心脏迷走神经传出活动，并提供了额外的证据，即椎体内血管紧张素II所产生的血压升高至少部分是由于心脏迷走神经张力降低所致。
