Devi Arti, Dwibedi Vagish, Jain Sahil, Kaur Gursharan, Khan Zaved Ahmed, Mandal Sudip Kumar, Shiven Aditya, Shah Kamal, Dewangan Hitesh Kumar, Rath Santosh Kumar
University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India.
Faculty of Life Sciences Baba Farid College, Muktsar Road, Bathinda, Punjab, India.
Curr Pharm Des. 2025;31(30):2416-2437. doi: 10.2174/0113816128344055250220100720.
SARS-CoV-2, the virus responsible for COVID-19, has resulted in a devastating global impact with millions of lives lost. Remdesivir and 2-DG are among the few drugs authorized for emergency use against COVID-19, but concerns about their efficacy and side effects persist. Vaccines have been developed and approved, yet the emergence of viral mutations has raised questions about their effectiveness against new variants. Natural compounds with antiviral properties have shown promise in combating SARS-CoV-2. The review highlights the potential of medicinal plant compounds, particularly in targeting the virus' main protease, a crucial component for viral replication. Natural, plant-derived compounds represent a promising avenue for COVID-19 therapeutics. Further clinical validation is necessary to ascertain their efficacy and safety in treating COVID-19. This underscores the importance of continued research into alternative treatments for combating this global health crisis. This review examines the potential of natural, plant-derived compounds as safe and cost-effective alternatives for combating COVID-19. It summarizes the pathogenesis of SARS-CoV- 2 and the ongoing drug studies and identifies natural compounds with known antiviral properties. Additionally, it explores the potential of medicinal plant compounds in targeting the SARS-CoV-2 main protease through and molecular docking studies.
导致新冠肺炎的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已在全球造成毁灭性影响，数百万人丧生。瑞德西韦和2-脱氧-D-葡萄糖是少数被批准用于紧急治疗新冠肺炎的药物，但人们对其疗效和副作用的担忧依然存在。疫苗已研发并获批，但病毒突变的出现引发了对其针对新变种有效性的质疑。具有抗病毒特性的天然化合物在对抗SARS-CoV-2方面显示出前景。该综述强调了药用植物化合物的潜力，特别是在靶向病毒主要蛋白酶方面，这是病毒复制的关键组成部分。天然的、植物来源的化合物是治疗新冠肺炎的一个有前景的途径。需要进一步的临床验证来确定它们在治疗新冠肺炎方面的疗效和安全性。这凸显了继续研究对抗这一全球健康危机的替代疗法的重要性。本综述探讨了天然的、植物来源的化合物作为对抗新冠肺炎的安全且经济有效的替代方案的潜力。它总结了SARS-CoV-2的发病机制以及正在进行的药物研究，并确定了具有已知抗病毒特性的天然化合物。此外，它还通过 和分子对接研究探索了药用植物化合物靶向SARS-CoV-2主要蛋白酶的潜力。
