Saini Aniket, Nandi Aniket, Gupta Ghanshyam Das, Sharma Ajay, Sharma Kalicharan
Department of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, G.T Road, Ghal Kalan, Moga, 142001, Punjab, India.
Department of Pharmaceutical Chemistry, Delhi Pharmaceutical Science, and Research University, New Delhi, 110017, India.
Curr Pharm Des. 2025;31(28):2282-2289. doi: 10.2174/0113816128353103250116112919.
To enhance curcumin's bioavailability with the help of carbon dot and piperine, due to its promising anticancer activity.
Cancer is a disease condition, where some cells grow uncontrollably, and if not controlled, they spread to other parts of the body. Concerning anticancer agents, curcumin has anticancer properties along with anti-inflammatory, antimicrobial, and antioxidant. Here in this study, the pharmacokinetic property was improved with the help of Carbon Dot encapsulation.
Bamboo leaves were used for the preparation of CDs and curcumin was loaded in them and the characterization for particle size, morphology, loading capacity, quantum yield, drug release in vitro studies, and cell viability activity as anticancer activity was done accordingly.
Prepared CDs have a smaller particle size (< 10 nm), good loading capacity, stability, and excellent fluorescence activity. Studies on the release of curcumin have shown that a pH-5.5 solution leads to enhanced curcumin release. The CDs-curcumin shows enhanced toxicity against cancerous cells than the curcumin even at lower concentrations (20, 40, 60, 80, 100 μM).
Curcumin can be delivered by CDs, which have the advantages of increased bioavailability, small size, high loading capacity, improved photoluminescence, and biocompatibility. These characteristics can result in improved anticancer activities even at low concentrations.
鉴于姜黄素具有可观的抗癌活性，借助碳点和胡椒碱提高其生物利用度。
癌症是一种疾病，某些细胞会不受控制地生长，若不加以控制，它们会扩散至身体的其他部位。关于抗癌药物，姜黄素具有抗癌特性，同时还具有抗炎、抗菌和抗氧化作用。在本研究中，借助碳点包封改善了其药代动力学特性。
使用竹叶制备碳点并将姜黄素载入其中，相应地进行了粒径、形态、载药量、量子产率、体外药物释放研究以及作为抗癌活性的细胞活力活性表征。
制备的碳点粒径较小（<10 nm），具有良好的载药量、稳定性和出色的荧光活性。姜黄素释放研究表明，pH 为 5.5 的溶液可增强姜黄素的释放。即使在较低浓度（20、40、60、80、100 μM）下，碳点 - 姜黄素对癌细胞的毒性也比姜黄素更强。
姜黄素可通过碳点递送，碳点具有生物利用度提高、尺寸小、载药量高、光致发光改善和生物相容性好等优点。这些特性即使在低浓度下也能提高抗癌活性。
