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Does allopurinol enhance efficacy of acute lymphoblastic leukemia maintenance therapy?

作者信息

Schmiegelow Kjeld, Toksvang Linea Natalie, Conter Valentino

机构信息

Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, The Faculty of Medicine, University of Copenhagen, Copenhagen.

Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen.

出版信息

Haematologica. 2025 Jul 1;110(7):1469-1471. doi: 10.3324/haematol.2024.287274. Epub 2025 Mar 20.

DOI:10.3324/haematol.2024.287274
PMID:40109196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12208150/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e1/12208150/4ea95e7f60ae/1101469.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e1/12208150/4ea95e7f60ae/1101469.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9e1/12208150/4ea95e7f60ae/1101469.fig1.jpg

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Does allopurinol enhance efficacy of acute lymphoblastic leukemia maintenance therapy?别嘌醇是否能提高急性淋巴细胞白血病维持治疗的疗效？
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本文引用的文献

1
Results from patient-derived xenograft models support co-administration of allopurinol and 6-mercaptopurine to reduce hepatotoxicity and improve event-free survival in pediatric acute lymphoblastic leukemia.患者来源的异种移植模型结果支持联合使用别嘌醇和6-巯基嘌呤，以降低小儿急性淋巴细胞白血病的肝毒性并改善无事件生存期。
Haematologica. 2025 Jul 1;110(7):1610-1615. doi: 10.3324/haematol.2024.286882. Epub 2025 Jan 16.
2
Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study.别嘌醇对未选择的小儿急性淋巴细胞白血病患者 6-巯基嘌呤代谢的影响：一项前瞻性 II 期研究。
Haematologica. 2024 Sep 1;109(9):2846-2853. doi: 10.3324/haematol.2023.284390.
3
Maintenance therapy for acute lymphoblastic leukemia: basic science and clinical translations.急性淋巴细胞白血病的维持治疗：基础科学与临床转化。
Leukemia. 2022 Jul;36(7):1749-1758. doi: 10.1038/s41375-022-01591-4. Epub 2022 Jun 2.
4
Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol.硫嘌呤增强 ALL 维持治疗（TEAM）：一项随机研究的研究方案，旨在评估在根据 ALLTogether1 方案中高危组中危组接受治疗的新发 B 细胞前体或 T 细胞急性淋巴细胞白血病患儿和成人患者（0-45 岁）中，通过添加极低剂量 6-硫鸟嘌呤到基于 6-巯基嘌呤/甲氨蝶呤的维持治疗中来改善无病生存。
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Increments in DNA-thioguanine level during thiopurine-enhanced maintenance therapy of acute lymphoblastic leukemia.在急性淋巴细胞白血病的硫唑嘌呤增强维持治疗期间，DNA-硫鸟嘌呤水平的增加。
Haematologica. 2021 Nov 1;106(11):2824-2833. doi: 10.3324/haematol.2020.278166.
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