Zerra Patricia, Bergsagel John, Keller Frank G, Lew Glen, Pauly Melinda
Emory University/Children's Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, Georgia.
Pediatr Blood Cancer. 2016 Apr;63(4):712-5. doi: 10.1002/pbc.25841. Epub 2015 Nov 24.
Mercaptopurine (6-mercaptopurine, 6MP) is a mainstay of curative therapy in childhood acute lymphoblastic leukemia (ALL), and contributes to its 90% overall survival rate. We present two patients with ALL who suffered with severe pancreatitis secondary to 6MP. Through the use of allopurinol in conjunction with reduced dose 6MP, we were able to continue 6MP without further pancreatitis. This report contributes to the small body of literature on 6MP associated pancreatitis in childhood ALL and describes a novel approach to continued use of 6MP during therapy.
巯嘌呤（6-巯基嘌呤，6MP）是儿童急性淋巴细胞白血病（ALL）根治性治疗的主要药物，对其90%的总生存率有贡献。我们报告了两名ALL患者，他们因6MP继发严重胰腺炎。通过联合使用别嘌醇和降低剂量的6MP，我们得以继续使用6MP而未再发生胰腺炎。本报告丰富了关于儿童ALL中6MP相关性胰腺炎的少量文献，并描述了治疗期间继续使用6MP的新方法。
