Is IDOL an Ideal Target for Treating Atherosclerosis?
作者信息
Zhu Liyuan, Lu Hong S, Daugherty Alan
机构信息
Department of Physiology, Saha Cardiovascular Research Center, Saha Aortic Center, Lexington, University of Kentucky.
出版信息
Arterioscler Thromb Vasc Biol. 2025 May;45(5):672-674. doi: 10.1161/ATVBAHA.125.322661. Epub 2025 Mar 20.
Abstract
摘要
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本文引用的文献
1
IDOL Deficiency Inhibits Cholesterol-Rich Diet-Induced Atherosclerosis in Rabbits.IDOL 缺乏抑制富含胆固醇饮食诱导的兔动脉粥样硬化。
Arterioscler Thromb Vasc Biol. 2025 May;45(5):669-671. doi: 10.1161/ATVBAHA.125.322417. Epub 2025 Mar 6.
2
Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia.载脂蛋白 E 基因缺失可预防家族性高胆固醇血症仓鼠模型的自发性动脉粥样硬化
Oxid Med Cell Longev. 2022 May 24;2022:1889632. doi: 10.1155/2022/1889632. eCollection 2022.
3
The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease.针对肝 X 受体治疗炎症性疾病的挑战与前景。
Pharmacol Ther. 2018 Jan;181:1-12. doi: 10.1016/j.pharmthera.2017.07.010. Epub 2017 Jul 16.
4
Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.LXR 激动剂对人脂质和脂蛋白代谢及循环中性粒细胞的有益和有害影响。
Cell Metab. 2016 Aug 9;24(2):223-33. doi: 10.1016/j.cmet.2016.07.016.
5
IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.IDOL N342S变异体、意大利普通人群中的动脉粥样硬化进展与心血管疾病
PLoS One. 2015 Apr 30;10(4):e0122414. doi: 10.1371/journal.pone.0122414. eCollection 2015.
6
The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.肝X受体-Idol轴对灵长类动物和小鼠的血浆低密度脂蛋白水平有不同的调节作用。
Cell Metab. 2014 Nov 4;20(5):910-918. doi: 10.1016/j.cmet.2014.10.001.
7
Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.用于人类动脉粥样硬化研究的兔模型：从病理生理机制到转化医学
Pharmacol Ther. 2015 Feb;146:104-19. doi: 10.1016/j.pharmthera.2014.09.009. Epub 2014 Sep 30.
8
Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.在循环中 LDL 水平较低的个体中，发现一种 LDL 受体变异体的功能丧失诱导降解剂。
Eur Heart J. 2013 May;34(17):1292-7. doi: 10.1093/eurheartj/ehs472. Epub 2013 Jan 16.
9
Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis.LXR-IDOL-LDLR 轴对胆固醇摄取的反馈调节。
Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2541-6. doi: 10.1161/ATVBAHA.112.250571. Epub 2012 Aug 30.
10
MYLIP p.N342S polymorphism is not associated with lipid profile in the Brazilian population.MYLIP p.N342S 多态性与巴西人群的血脂谱无关。
Lipids Health Dis. 2012 Jun 28;11:83. doi: 10.1186/1476-511X-11-83.
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