Jansson R, Steen G, Svanvik J
Department of Surgery I and III, University of Göteborg, Sahlgrenska sjukhuset, Sweden.
Gastroenterology. 1978 Jul;75(1):47-50.
The influence of vasoactive intestinal peptide (VIP) on the concentrating mechanism and the motility in the feline gallbladder has been studied in vivo. A perfusion technique made possible a simultaneous study of the motility and of the net transport of water and electrolytes across the gallbladder wall. It was found that an intravenous infusion of VIP relaxes the gallbladder and induces a net fluid secretion into its lumen. The net absorption of chloride ions was markedly reduced, whereas the net transport of sodium, potassium, and bicarbonate was reversed from an absorption into a secretion. Owing to the presence of VIP-containing nerve fibers in the gallbladder wall, a physiological significance for the secretory gallbladder response to VIP is suggested.
在活体状态下研究了血管活性肠肽（VIP）对猫胆囊浓缩机制及运动的影响。一种灌注技术使得能够同时研究胆囊运动以及水和电解质跨胆囊壁的净转运。研究发现，静脉输注VIP可使胆囊舒张，并诱导液体向胆囊腔内净分泌。氯离子的净吸收显著减少，而钠、钾和碳酸氢根的净转运则从吸收转变为分泌。鉴于胆囊壁中存在含VIP的神经纤维，提示胆囊对VIP的分泌反应具有生理意义。
