Knockaert Nienke, Huysentruyt Koen, Hegar Badriul, Franco Jackeline Motta, Santos Macedo Victor Ravel, Fontes Vieira Sarah Cristina, Vandenplas Yvan
KidZ Health Castle, UZ Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Department of Child Health, Faculty Medicine Universitas Indonesia, Jakarta, Indonesia.
Pediatr Gastroenterol Hepatol Nutr. 2025 Mar;28(2):124-134. doi: 10.5223/pghn.2025.28.2.124. Epub 2025 Mar 5.
The Cow's Milk-related Symptom Score (CoMiSS) improves the recognition of cow milk allergy (CMA) symptoms. A score of ≥10 should raise awareness of CMA. The median CoMiSS in healthy European infants aged <6 months is 3. This study aimed to determine the impact of different regions on CoMiSS in healthy infants aged <12 months to evaluate regional and age-related differences.
A prospective cross-sectional study was conducted at one hospital each in Indonesia (Jakarta) and Brazil (Sergipe). CoMiSS was assessed in healthy infants aged -12 months old.
In Jakarta, a total of 286 infants (50.7% boys) were included. The median (interquartile range) CoMiSS was 1.5 (0-4); the 95th percentile was 7. In Sergipe, 101 infants (60.4% boys) were included. The median (interquartile range) CoMiSS was 4 (4-6); the 95th centile was 10.9. Age (odds ratio [OR], 0.96; 95% confidence interval [CI], 0.94-0.99; <0.001) and country (OR, 2.40; 95% CI, 2.06-2.79; <0.001) were significant independent predictors of changes in mean CoMiSS in a linear regression model (r=0.27).
Median CoMiSS in healthy infants differed between Jakarta and Sergipe (1.5 vs. 4.0). These findings highlight that the perceived normality of parents may be region-dependent.
牛奶相关症状评分（CoMiSS）有助于提高对牛奶过敏（CMA）症状的识别。评分≥10应提高对CMA的警惕。欧洲6个月以下健康婴儿的CoMiSS中位数为3。本研究旨在确定不同地区对12个月以下健康婴儿CoMiSS的影响，以评估地区和年龄相关差异。
在印度尼西亚（雅加达）和巴西（塞尔希培）的各一家医院进行了一项前瞻性横断面研究。对12个月以下的健康婴儿进行CoMiSS评估。
在雅加达，共纳入286名婴儿（50.7%为男孩）。CoMiSS中位数（四分位间距）为1.5（0-4）；第95百分位数为7。在塞尔希培，纳入101名婴儿（60.4%为男孩）。CoMiSS中位数（四分位间距）为4（4-6）；第95百分位数为10.9。在一个线性回归模型（r=0.27）中，年龄（比值比[OR]，0.96；95%置信区间[CI]，0.94-0.99；<0.001）和国家（OR，2.40；95%CI，2.06-2.79；<0.001）是平均CoMiSS变化的显著独立预测因素。
雅加达和塞尔希培健康婴儿的CoMiSS中位数不同（1.5对4.0）。这些发现突出表明，父母对症状正常与否的认知可能因地区而异。
