Kloub Mohammad, Elfert Khaled A, Rosado Flor, Elnajjar Ahmed, Eldesouki Mohamed, Abusalim Abdul-Rahman I
Department of Internal Medicine, Saint Michael's Medical Center, New York Medical College, Newark, USA.
Department of Internal Medicine, St. Barnabas Hospital Health System, New York, USA.
Cureus. 2025 Feb 15;17(2):e79068. doi: 10.7759/cureus.79068. eCollection 2025 Feb.
Autoimmune hepatitis is an autoimmune liver condition of uncertain etiology. Environmental triggers have been involved in the pathophysiology of the disease. The triggers include viruses, immunizations, and drugs. Since the emergence of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been implicated in the development of various autoimmune diseases. We report the case of a 58-year-old patient who had persistent elevation in liver transaminase levels after COVID-19 infection. After undergoing a liver biopsy, he was diagnosed with seronegative autoimmune hepatitis with an excellent response to steroids. Our case highlights the importance of considering the diagnosis of autoimmune hepatitis in patients with persistent elevation of liver transaminases after COVID-19 infection.
自身免疫性肝炎是一种病因不明的自身免疫性肝脏疾病。环境触发因素参与了该疾病的病理生理学过程。这些触发因素包括病毒、免疫接种和药物。自2019年冠状病毒病（COVID-19）大流行出现以来，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）被认为与各种自身免疫性疾病的发生有关。我们报告了一例58岁患者的病例，该患者在感染COVID-19后肝转氨酶水平持续升高。在进行肝活检后，他被诊断为血清阴性自身免疫性肝炎，对类固醇治疗反应良好。我们的病例强调了在COVID-19感染后肝转氨酶持续升高的患者中考虑自身免疫性肝炎诊断的重要性。
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