Beyene Dessale Abate, Demsie Desalegn Getnet, Tafere Chernet, Yazie Taklo Simeneh, Endeshaw Destaw, Tadesse Tamrat Assefa, Addisu Zenaw Debasu
Department of Pharmacy, Asrat Woldeyes Health Science Campus, Debre Berhan University, Debre Birhan, Ethiopia.
Department of Pharmacology, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Amhara, Ethiopia.
Front Neurol. 2025 Mar 5;16:1546911. doi: 10.3389/fneur.2025.1546911. eCollection 2025.
Epilepsy is a major public health issue worldwide, often leading to physical and cognitive impairments that limit employment, independence, and social interaction. Health-related quality of life (HRQoL) is a crucial outcome in the treatment of chronic epilepsy as it is linked to reduced independence, treatment challenges, and lower life expectancy. HRQoL serves as an important health indicator for assessing the impact of the disease on daily living activities.
This study aimed to estimate the mean score of health-related quality of life (HRQoL) and factors associated with lower HRQoL in people living with epilepsy (PLWE) in sub-Saharan African (SSA) countries.
A comprehensive literature search was conducted using PubMed, Cochrane Library, Scopus, and Google Scholar databases. This review has been registered with PROSPERO (CRD42024620363). The eligibility criteria were established, and this review included cross-sectional and observational studies assessing HRQOL in PLWE in SSA countries, published in English from the inception of databases through November 2024. The pooled HRQoL was reported as the mean score with accompanying 95% confidence intervals. Finally, publication bias was evaluated using a funnel plot and Egger's regression test.
The pooled mean score of HRQoL among PLWE in SSA was 63.79 (95% CI: 59.75-67.84%). Owing to significant heterogeneity across the studies, a random-effects model was utilized for the meta-analysis (I = 98.96%, < 0.001). This meta-analysis indicated that anxiety ( = -4.762, = 0.0029), depression ( = -4.591, < 0.0001), uncontrolled seizures ( = -4.321, < 0.0001), and a family history of epilepsy ( = -5.093, = 0.0013) had statistically significant negative impacts on HRQoL in PLWE. Despite some asymmetry in the funnel plot, Egger's test showed no significant publication bias, with a -value of 0.321.
This review found a moderate pooled mean score of HRQoL among PLWE in SSA countries. Factors that negatively affect HRQoL in these regions include anxiety, depression, uncontrolled seizures, comorbidities, and a family history of epilepsy.
https://www.crd.york.ac.uk/PROSPERO/search, identifier CRD42024620363.
癫痫是一个全球性的重大公共卫生问题，常常导致身体和认知障碍，限制就业、独立性和社交互动。健康相关生活质量（HRQoL）是慢性癫痫治疗中的一个关键结果，因为它与独立性降低、治疗挑战和预期寿命缩短有关。HRQoL是评估该疾病对日常生活活动影响的重要健康指标。
本研究旨在估计撒哈拉以南非洲（SSA）国家癫痫患者（PLWE）的健康相关生活质量（HRQoL）平均得分以及与较低HRQoL相关的因素。
使用PubMed、Cochrane图书馆、Scopus和谷歌学术数据库进行了全面的文献检索。本综述已在PROSPERO（CRD42024620363）注册。确定了纳入标准，本综述纳入了评估SSA国家PLWE的HRQOL的横断面和观察性研究，这些研究自数据库建立至2024年11月以英文发表。汇总的HRQoL报告为平均得分及伴随的95%置信区间。最后，使用漏斗图和Egger回归检验评估发表偏倚。
SSA地区PLWE的HRQoL汇总平均得分为63.79（95%CI：59.75 - 67.84%）。由于各研究间存在显著异质性，采用随机效应模型进行荟萃分析（I² = 98.96%，P < 0.001）。该荟萃分析表明，焦虑（β = -4.762，P = 0.0029）、抑郁（β = -4.591，P < 0.0001）、癫痫发作未得到控制（β = -4.321，P < 0.0001）以及癫痫家族史（β = -5.093，P = 0.0013）对PLWE的HRQoL具有统计学显著的负面影响。尽管漏斗图存在一定不对称性，但Egger检验显示无显著发表偏倚，P值为0.321。
本综述发现SSA国家PLWE的HRQoL汇总平均得分中等。这些地区对HRQoL产生负面影响的因素包括焦虑、抑郁、癫痫发作未得到控制、合并症以及癫痫家族史。
https://www.crd.york.ac.uk/PROSPERO/search，标识符CRD42024620363
