Liu Jinfeng, Han Xinhui, Wang Qingyi, Qin Sihui, Xi Yujie, Liang Guoying
School of Clinical Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Department of Gastroenterology 1, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Front Oncol. 2025 Mar 5;15:1523465. doi: 10.3389/fonc.2025.1523465. eCollection 2025.
Gastric cancer (GC) is a type of malignant tumor that seriously endangers human health. As the understanding of the mechanisms underlying gastric cancer deepens, in recent years, investigations on gastric cancer stem cells (GCSCs) have garnered significant interest. They are pivotal in the onset, progression, recurrence, and pharmacoresistance of GC. Comprehensive research on GCSCs is expected to provide new strategies for the diagnosis and treatment of GC. This article endeavors to comprehensively assess the current status and future trends of GCSCs research through bibliometric analysis, thereby providing a valuable reference for further in - depth studies in this field.
English - language academic journals related to GCSCs research in the Web of Science database were retrieved. Subsequently, VOSviewer was utilized to conduct network collinear analysis of the exported source institutions, literature authors, references, and keywords. And CiteSpace was used to perform statistical analysis of the annual publication count, keyword clustering, references, and keyword burst.
A total of 3882 documents that met the criteria were incorporated. The quantity of published papers has shown a consistent upward trend annually since 2003. Among the authors of the literature, multiple stable core author groups represented by Zhu, Wei, Wang, Mei, Xu, Wenrong, etc. have been formed. There are 335 associated institutions in total. The Japan National Cancer Center has the strongest relevance and the largest number of published papers. There are 7 clustering labels formed among the keywords, including main clustering modules such as activation, cancer stem cells, DNA content aneuploidy, and expression. 25 burst keywords were generated, and the burst keywords in the past two years include mesenchymal stem cells, drug resistance, proliferation, etc. The emergence of references indicates that eight references have been cited up to now and are the focus of current research.
The research overview of GCSCs in the past 30 years was visually presented by visual maps. In the past decade, scholars' research in this field has gradually intensified, and the development trend is good. Through the deeper study of the GCSCs mechanism, intervention GCSCs in the future will be a new promising treatment approach for GC patients. This hot topic still deserves more attention in the future.
胃癌（GC）是一种严重危害人类健康的恶性肿瘤。随着对胃癌发病机制认识的不断深入，近年来，关于胃癌干细胞（GCSCs）的研究备受关注。它们在胃癌的发生、发展、复发及耐药中起关键作用。对GCSCs进行全面研究有望为胃癌的诊断和治疗提供新策略。本文试图通过文献计量分析全面评估GCSCs研究的现状和未来趋势，从而为该领域的进一步深入研究提供有价值的参考。
检索Web of Science数据库中与GCSCs研究相关的英文科技期刊。随后，利用VOSviewer对导出的来源机构、文献作者、参考文献和关键词进行网络共线分析。并使用CiteSpace对年度发文量、关键词聚类、参考文献和关键词突现进行统计分析。
共纳入3882篇符合标准的文献。自2003年以来，发表论文数量呈逐年上升趋势。在文献作者中，形成了以朱、魏、王、梅、徐、文荣等为代表的多个稳定的核心作者群体。共有335个相关机构。日本国立癌症中心的相关性最强，发表论文数量最多。关键词之间形成了7个聚类标签，包括激活、癌症干细胞、DNA含量非整倍体和表达等主要聚类模块。产生了25个突现关键词，近两年的突现关键词包括间充质干细胞、耐药性、增殖等。参考文献的出现表明，目前有8篇参考文献被引用，是当前研究的重点。
通过可视化图谱直观呈现了过去30年GCSCs的研究概况。在过去十年中，学者们对该领域的研究逐渐加强，发展态势良好。通过对GCSCs机制的深入研究，未来干预GCSCs将是胃癌患者一种有前景的新治疗方法。这一热点话题在未来仍值得更多关注。
