Development of Repetitive Mechanical Oscillation Needle-Free Injection through Electrically Induced Microbubbles.

We previously developed a novel needle-free reagent injection method based on electrically induced microbubbles. The system generates microbubbles and applies repetitive mechanical oscillation associated with microbubble dynamics to perforate tissue and introduce a reagent. In this paper, we propose improving the reagent injection depth by reflecting the shock wave through microbubble dynamics. Our results show that the developed shock wave reflection method improves the ability of the electrically induced microbubble injection system to introduce a reagent. The method extends the application potential of electrically induced microbubble needle-free injection.