Carney J M, Seale T W, Logan L, McMaster S B
Neurosci Lett. 1985 May 1;56(1):27-31. doi: 10.1016/0304-3940(85)90435-5.
Male CBA/J and SWR/J mice were tested with doses of caffeine, theophylline and 8-p-sulfophenyltheophylline (xanthine). Caffeine produced dose-related decreases in locomotor activity and colonic temperatures in SWR/J mice. However, caffeine produced increases in locomotor activity and failed to lower the body temperature of CBA/J mice. Theophylline produced a decrease in body temperature of SWR/J mice. Comparison of brain caffeine levels demonstrated no difference in brain pharmacokinetics. The peripherally active xanthine failed to alter body temperature at the same molar dose as that of theophylline. These data clearly demonstrate that genetic differences in the effects of methylxanthine are due to inherent differences in the central nervous system sensitivity of the two strains. The data further indicate that while differences in xanthine metabolism may occur in inbred mice, these differences are not a major factor in the acute, peak plasma level, effects of xanthines.
对雄性CBA/J和SWR/J小鼠使用不同剂量的咖啡因、茶碱和8 - 对 - 磺基苯基茶碱（黄嘌呤）进行测试。咖啡因使SWR/J小鼠的运动活性和结肠温度呈剂量相关下降。然而，咖啡因使CBA/J小鼠的运动活性增加，且未能降低其体温。茶碱使SWR/J小鼠的体温下降。脑咖啡因水平的比较表明脑药代动力学无差异。外周活性黄嘌呤在与茶碱相同摩尔剂量时未能改变体温。这些数据清楚地表明，甲基黄嘌呤作用的遗传差异是由于这两个品系中枢神经系统敏感性的固有差异。数据进一步表明，虽然近交系小鼠中可能存在黄嘌呤代谢差异，但这些差异不是黄嘌呤急性、血浆峰值水平效应的主要因素。
