Zyoud Sa'ed H, Ahmad Tauseef, Al-Jabi Samah W
Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Clinical Research Centre, An-Najah National University Hospital, Nablus, 44839, Palestine.
Aesthetic Plast Surg. 2025 Mar 20. doi: 10.1007/s00266-025-04823-x.
Skin aging is a multifaceted biological process influenced by both intrinsic and extrinsic factors. It involves changes at the tissue, cellular, and molecular levels. Recently, clinical trials have provided growing evidence across various aspects of skin aging. This study provides a thorough analysis of scientific publications on clinical trials related to skin aging. It includes publications indexed in the Scopus database between 2005 and 2024, retrieved using a wide array of pertinent keywords. Following this, network analysis and visualization were performed with VOSviewer (v. 1.6.20) to map research trends and pinpoint emerging research hotspots. From 2005 to 2024, 550 publications investigated the relationship between clinical trials and skin aging. Over the past two decades, the number of publications in this field has increased significantly (R = 0.9346; p < 0.001), from seven in 2005 to 93 in 2024. This growth can be divided into two phases: a gradual increase from 2005 to 2015, followed by a period of rapid expansion from 2016 to 2024. The United States leads with 128 publications, representing 23.27% of the total. South Korea ranks second with 81 publications (14.73%), China ranks third with 54 publications (9.82%), and Italy ranks fourth with 49 publications (8.91%). Recent studies have concentrated on several key areas, including "topical anti-aging treatments and nutraceuticals," "patient safety and satisfaction in laser and light-based therapies, with a focus on adverse effects and clinical trial findings," and "clinical trials examining oral supplements for skin wrinkling and aging." This analysis underscores the pressing need for ongoing research and collaboration to enhance patient outcomes and the efficacy of anti-aging treatments, especially those involving topical treatments, nutraceuticals, and oral supplements.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
皮肤老化是一个受内在和外在因素影响的多方面生物学过程。它涉及组织、细胞和分子水平的变化。最近，临床试验在皮肤老化的各个方面提供了越来越多的证据。本研究对与皮肤老化相关的临床试验的科学出版物进行了全面分析。它包括2005年至2024年在Scopus数据库中索引的出版物，使用大量相关关键词进行检索。在此之后，使用VOSviewer（v. 1.6.20）进行网络分析和可视化，以绘制研究趋势并确定新兴研究热点。2005年至2024年，有550篇出版物研究了临床试验与皮肤老化之间的关系。在过去二十年中，该领域的出版物数量显著增加（R = 0.9346；p < 0.001），从2005年的7篇增加到2024年的93篇。这种增长可分为两个阶段：2005年至2015年逐渐增加，随后是2016年至2024年的快速扩张期。美国以128篇出版物领先，占总数的23.27%。韩国以81篇出版物排名第二（14.73%），中国以54篇出版物排名第三（9.82%），意大利以49篇出版物排名第四（8.91%）。最近的研究集中在几个关键领域，包括“局部抗衰老治疗和营养保健品”、“激光和光基治疗中的患者安全性和满意度，重点是不良反应和临床试验结果”以及“研究口服补充剂对皮肤皱纹和老化影响的临床试验”。该分析强调了持续研究和合作的迫切需求，以改善患者预后和抗衰老治疗的疗效，特别是那些涉及局部治疗、营养保健品和口服补充剂的治疗。证据水平V 本杂志要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述，请参阅目录或在线作者指南 www.springer.com/00266 。
