Zyoud Sa'ed H
Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus, 44839, Palestine.
Clinical Research Centre, An-Najah National University Hospital, Nablus, 44839, Palestine.
Aesthetic Plast Surg. 2025 Mar 20. doi: 10.1007/s00266-025-04820-0.
Epidermal growth factor (EGF) is essential for both wound repair and the maintenance of healthy tissues. Numerous bibliometric studies have been published on wound healing; however, none have focused on EGF in wound healing. This study comprehensively analyzed scientific publications on the role of Epidermal Growth Factor (EGF) in wound healing. The analysis encompassed publications indexed in the Scopus database from 1972 to 2024, retrieved using a broad range of relevant keywords. Network analysis and visualization were subsequently conducted using VOSviewer (v. 1.6.20) to map research trends and identify research hotspots. My examination of the Scopus database identified 3122 articles on the use of EGF in wound healing published over the past 48 years (1972-2024). Most of these publications were research articles (n = 2812; 90.07%), followed by review articles (n = 244; 7.82%). The number of publications on the use of EGF in wound healing has increased significantly (R=0.9449; p < 0.001) over the years. This study revealed that, during the past ten years, there has been an increasing amount of global research on the relationship between EGF and wound healing. The effectiveness and clinical applications of human EGF and EGFR signaling in cancer-related wound healing were the main topics of our study, which focused on EGF and wound healing overall. To improve patient outcomes and enhance the efficacy of wound healing, particularly in aesthetic and reconstructive surgery, this bibliometric analysis emphasizes the importance of ongoing research and collaboration in this field.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
表皮生长因子（EGF）对于伤口修复和健康组织的维持都至关重要。关于伤口愈合已经发表了大量文献计量学研究；然而，尚无研究聚焦于伤口愈合中的EGF。本研究全面分析了关于表皮生长因子（EGF）在伤口愈合中作用的科学出版物。分析涵盖了1972年至2024年在Scopus数据库中索引的出版物，使用了广泛的相关关键词进行检索。随后使用VOSviewer（v. 1.6.20）进行网络分析和可视化，以绘制研究趋势并识别研究热点。我对Scopus数据库的检索发现，在过去48年（1972 - 2024年）中有3122篇关于EGF在伤口愈合中应用的文章。这些出版物大多是研究论文（n = 2812；90.07%），其次是综述文章（n = 244；7.82%）。多年来，关于EGF在伤口愈合中应用的出版物数量显著增加（R = 0.9449；p < 0.001）。本研究表明，在过去十年中，全球对EGF与伤口愈合之间关系的研究越来越多。人EGF和EGFR信号在癌症相关伤口愈合中的有效性和临床应用是我们研究的主要主题，该研究总体上聚焦于EGF与伤口愈合。为了改善患者预后并提高伤口愈合的疗效，特别是在美容和重建手术中，本文献计量分析强调了该领域持续研究和合作的重要性。证据水平V 本期刊要求作者为每篇文章指定证据水平。有关这些循证医学评级的完整描述，请参阅目录或作者在线指南www.springer.com/00266 。
