Isenberg S J, Abrams C, Hyman P E
Ophthalmology. 1985 May;92(5):698-700. doi: 10.1016/s0161-6420(85)33979-9.
Because of a report of necrotizing enterocolitis and death of a neonate from cyclopentolate eyedrops, we prospectively studied the effects of cyclopentolate 0.5% and 0.25% ophthalmic solutions and of a placebo on gastric volume and acid secretions in 20 pre-term infants. Placebo and cyclopentolate 0.25% eyedrops had no significant effect on the tested gastric functions. However, cyclopentolate 0.5% eyedrops significantly decreased gastric acid secretion and volume. Since this effect may predispose to the development of gastroenteritis, we recommend that cyclopentolate 0.5% be avoided in preterm infants; a weaker concentration of cyclopentolate eyedrops, however, can be used for mydriasis.
由于有报告称一名新生儿因使用环喷托酯眼药水而发生坏死性小肠结肠炎并死亡，我们对20名早产儿进行了前瞻性研究，观察0.5%和0.25%的环喷托酯眼药水以及一种安慰剂对胃容量和胃酸分泌的影响。安慰剂和0.25%的环喷托酯眼药水对所测试的胃功能没有显著影响。然而，0.5%的环喷托酯眼药水显著降低了胃酸分泌和胃容量。由于这种作用可能易引发肠胃炎，我们建议避免在早产儿中使用0.5%的环喷托酯；不过，浓度较低的环喷托酯眼药水可用于散瞳。
