Ozgun Uygur, Demet Terek, Ozge Koroglu A, Zafer Dokumcu, Murat Sezak, Mehmet Yalaz, Nilgun Kultursay
Department of Pediatrics, Division of Neonatology, Ege University, Faculty of Medicine, Izmir, Turkey.
Department of Pediatric Surgery, Ege University, Faculty of Medicine, Izmir, Turkey.
J Coll Physicians Surg Pak. 2014 May;24 Suppl 2:S147-9.
Retinopathy of prematurity (ROP) is a serious problem of preterm infants which may lead to impairment of vision and even to blindness if untreated. Routine eye examination is necessary for early diagnosis and treatment of ROP in preterm infants. Mydriatic eye drops (cyclopentolate, tropicamide and phenylephrine) are applied before the ophthalmic examination. These agents are rarely absorbed to systemic circulation and in some cases result with serious side effects like skin rash, tachycardia, feeding intolerance, discomfort, apnea, gastric dilatation and ileus, despite different treatment models and dosage reducing strategies. We report here a preterm patient who died because of severe diffuse necrotizing enterocolitis (NEC) after topical application of 0.5% cyclopentolate and 1.25% phenylephrine during ROP screening to emphasise the serious side effects of these agents.
早产儿视网膜病变（ROP）是早产儿面临的一个严重问题，如果不治疗，可能会导致视力受损甚至失明。对早产儿进行常规眼部检查对于ROP的早期诊断和治疗至关重要。在眼科检查前需使用散瞳眼药水（环喷托酯、托吡卡胺和去氧肾上腺素）。尽管有不同的治疗模式和剂量减少策略，但这些药物很少被吸收进入体循环，在某些情况下会导致严重的副作用，如皮疹、心动过速、喂养不耐受、不适、呼吸暂停、胃扩张和肠梗阻。我们在此报告一名早产儿患者，其在ROP筛查期间局部应用0.5%环喷托酯和1.25%去氧肾上腺素后因严重弥漫性坏死性小肠结肠炎（NEC）死亡，以强调这些药物的严重副作用。
