Laws D E, Morton C, Weindling M, Clark D
Department of Ophthalmology, Walton Hospital, Liverpool.
Br J Ophthalmol. 1996 May;80(5):425-8. doi: 10.1136/bjo.80.5.425.
To detect systemic complications of screening for retinopathy of prematurity (ROP), paying particular attention to the physical examination.
Oxygen saturation, pulse rate, and blood pressure were monitored before, during, and after 110 ROP screening examinations.
Following topical mydriatics diastolic blood pressure was elevated by a mean of 6 (SD 7.2) mm Hg. Immediately after the examination there was a further rise in both systolic and diastolic pressure of 4.3 (14.5) mm Hg and 3.3 (11.6) mm Hg, respectively. Oxygen saturation and pulse rate remained stable during the control period and administration of eyedrops. Saturation fell by a median of 3% (95% confidence interval plus or minus 1.2%) after the examination while there was rise in pulse rate of 7 (SD 23.1) beats per minute. This change in pulse rate was not observed in infants on concurrent methylxanthine therapy. No infant had clinically significant changes at the end of the study.
The initial changes in blood pressure may represent side effects of topical mydriatics but the later changes following the physical examination may be an additional response to the stress of ROP screening.
检测早产儿视网膜病变（ROP）筛查的全身并发症，尤其关注体格检查。
在110次ROP筛查检查前、检查期间及检查后监测血氧饱和度、脉搏率和血压。
使用局部散瞳剂后，舒张压平均升高6（标准差7.2）mmHg。检查刚结束后，收缩压和舒张压又分别进一步升高4.3（14.5）mmHg和3.3（11.6）mmHg。在对照期和滴眼药水期间，血氧饱和度和脉搏率保持稳定。检查后，血氧饱和度中位数下降3%（95%置信区间加减1.2%），而脉搏率每分钟上升7（标准差23.1）次。在同时接受甲基黄嘌呤治疗的婴儿中未观察到这种脉搏率变化。研究结束时，没有婴儿出现具有临床意义的变化。
血压的初始变化可能代表局部散瞳剂的副作用，但体格检查后的后续变化可能是对ROP筛查应激的额外反应。
