Hashim Prianka H, Perry Madeline J, Pritchard Michele T, Gerton Jennifer L, Duncan Francesca E
Reproduction. 2025 Apr 1;169(5). doi: 10.1530/REP-25-0042. Print 2025 May 1.
We synthesize current evidence that granulosa cells possess unique innate immune signaling capabilities. We suggest the novel concept that this serves as a quality control surveillance mechanism by integrating signals from the oocyte and ovarian microenvironment to prevent poor-quality follicles from producing gametes that contribute to the next generation.
我们综合了当前的证据，即颗粒细胞具有独特的先天免疫信号传导能力。我们提出了一个新颖的概念，即这作为一种质量控制监测机制，通过整合来自卵母细胞和卵巢微环境的信号，防止质量差的卵泡产生对下一代有贡献的配子。
