糖尿病和载脂蛋白L1（APOL1）基因型会增加镰状细胞病患者慢性肾病进展的风险。
Diabetes mellitus and APOL1 genotype increase the risk for chronic kidney disease progression in sickle cell disease.
作者信息
Sun Ryan, Srivastava Anand, Zapater Joseph L, Njoku Franklin, Han Jin, Ivy Zalaya, Farooqui Marwah, Rizvi Insia, Layden Brian, Molokie Robert E, Gordeuk Victor R, Saraf Santosh L
机构信息
Division of Hematology and Oncology, Department of Medicine, University of Illinois Chicago, Chicago, IL.
Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL.
出版信息
Blood. 2025 Jun 12;145(24):2927-2930. doi: 10.1182/blood.2024027839.
Abstract
We observed diabetes mellitus (DM) in 9.3% of adults with sickle cell disease (SCD), and DM predicted a sevenfold greater risk of chronic kidney disease progression adjusting for high-risk APOL1. Our results emphasize the clinical significance of DM in SCD.
摘要
我们在9.3%的镰状细胞病（SCD）成年患者中观察到糖尿病（DM），并且在对高危APOL1进行校正后，糖尿病预示着慢性肾病进展风险高出7倍。我们的结果强调了糖尿病在镰状细胞病中的临床意义。
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本文引用的文献
1
Inaxaplin for Proteinuric Kidney Disease in Persons with Two Variants.Inaxaplin 用于伴有两种变异的蛋白尿性肾病患者。
N Engl J Med. 2023 Mar 16;388(11):969-979. doi: 10.1056/NEJMoa2202396.
2
Type 2 diabetes mellitus burdens among adults with sickle cell disease: A 12-year single health system-based cohort analysis.镰状细胞病成人患者中的2型糖尿病负担：一项基于单一医疗系统的12年队列分析。
EJHaem. 2021 Jan 4;2(1):94-98. doi: 10.1002/jha2.161. eCollection 2021 Feb.
3
The nephropathy of sickle cell trait and sickle cell disease.镰状细胞性状和镰状细胞病的肾病
Nat Rev Nephrol. 2022 Jun;18(6):361-377. doi: 10.1038/s41581-022-00540-9. Epub 2022 Feb 21.
4
New Creatinine- and Cystatin C-Based Equations to Estimate GFR without Race.新型基于肌酐和胱抑素 C 的估算肾小球滤过率方程，无需考虑种族因素。
N Engl J Med. 2021 Nov 4;385(19):1737-1749. doi: 10.1056/NEJMoa2102953. Epub 2021 Sep 23.
5
Dapagliflozin in Patients with Chronic Kidney Disease.达格列净治疗慢性肾脏病患者。
N Engl J Med. 2020 Oct 8;383(15):1436-1446. doi: 10.1056/NEJMoa2024816. Epub 2020 Sep 24.
6
Prevalence of Diabetes by Race and Ethnicity in the United States, 2011-2016.美国 2011-2016 年按种族和民族划分的糖尿病患病率。
JAMA. 2019 Dec 24;322(24):2389-2398. doi: 10.1001/jama.2019.19365.
7
Kidney Function Decline among Black Patients with Sickle Cell Trait and Sickle Cell Disease: An Observational Cohort Study.黑人镰状细胞特征和镰状细胞病患者的肾功能下降：一项观察性队列研究。
J Am Soc Nephrol. 2020 Feb;31(2):393-404. doi: 10.1681/ASN.2019050502. Epub 2019 Dec 6.
8
Children with sickle cell anemia and APOL1 genetic variants develop albuminuria early in life.患有镰状细胞贫血和APOL1基因变异的儿童在生命早期就会出现蛋白尿。
Haematologica. 2019 Sep;104(9):e385-e387. doi: 10.3324/haematol.2018.212779. Epub 2019 Mar 19.
9
Progressive Decline in Estimated GFR in Patients With Sickle Cell Disease: An Observational Cohort Study.镰状细胞病患者估算肾小球滤过率的逐渐下降：一项观察性队列研究。
Am J Kidney Dis. 2019 Jul;74(1):47-55. doi: 10.1053/j.ajkd.2018.12.027. Epub 2019 Feb 21.
10
Similar burden of type 2 diabetes among adult patients with sickle cell disease relative to African Americans in the U.S. population: a six-year population-based cohort analysis.美国人群中成年镰状细胞病患者与非裔美国人相比，2 型糖尿病负担相似：一项六年基于人群的队列分析。
Br J Haematol. 2019 Apr;185(1):116-127. doi: 10.1111/bjh.15773. Epub 2019 Feb 3.
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