环磷酰胺在感染犬弓首蛔虫的SJL小鼠中诱导显著嗜酸性粒细胞增多。

Induction of a marked eosinophilia by cyclophosphamide in Toxocara canis infected SJL mice.

作者信息

Sugane K, Oshima T

出版信息

Parasite Immunol. 1985 May;7(3):255-63. doi: 10.1111/j.1365-3024.1985.tb00074.x.

DOI:10.1111/j.1365-3024.1985.tb00074.x

Abstract

Cyclophosphamide (Cy) is known to produce a marked eosinophilia in mice after antigen challenge. In this study, we studied the effect of Cy on eosinophilia in helminthic infection. Peripheral blood eosinophils were counted in SJL mice following a large dose of Cy injection, infection with Toxocara canis, and both Cy injection and T. canis infection simultaneously. Following the injection with Cy (150 mg/kg), the eosinophil counts fell sharply, then rose abruptly to six times the normal level followed by a decrease. Infection with T. canis induced eosinophilia in mice. However, when mice were both infected with T. canis and given Cy injection, the eosinophilia was markedly enhanced. The results suggest that the marked eosinophilia in mice induced by Cy is not only observed in antigen challenge but also in helminthic infection.

摘要

已知环磷酰胺（Cy）在抗原攻击后会使小鼠产生明显的嗜酸性粒细胞增多。在本研究中，我们研究了Cy对蠕虫感染中嗜酸性粒细胞增多的影响。在给SJL小鼠注射大剂量Cy、感染犬弓首蛔虫以及同时进行Cy注射和犬弓首蛔虫感染后，对其外周血嗜酸性粒细胞进行计数。注射Cy（150mg/kg）后，嗜酸性粒细胞计数急剧下降，然后突然升至正常水平的六倍，随后又下降。犬弓首蛔虫感染可诱导小鼠嗜酸性粒细胞增多。然而，当小鼠同时感染犬弓首蛔虫并注射Cy时，嗜酸性粒细胞增多明显增强。结果表明，Cy诱导的小鼠明显嗜酸性粒细胞增多不仅在抗原攻击中可见，在蠕虫感染中也可见。