Sugane K, Oshima T
Parasite Immunol. 1984 Sep;6(5):409-20. doi: 10.1111/j.1365-3024.1984.tb00812.x.
In order to elucidate the relationship between eosinophilia and IgE antibody production in parasitic infection, the degree of eosinophilia and IgE antibody levels to larval ES antigen of Toxocara canis were investigated in eight inbred strains of mice after infection with T. canis. Eosinophilia was far higher in degree in SJL mice than in the other inbred strains. However, IgE antibody levels to larval ES antigen in SJL mice were the lowest among those inbred strains. Similarly, the degree of eosinophilia in AKR mice was slightly higher than those in the other strains except SJL mice, but IgE antibody levels to larval ES antigen in AKR mice was as low as that in SJL mice. Consequently, high responders for eosinophilia were not always high responders for IgE antibody production to larval ES antigen. Inheritance of the two traits, marked eosinophilia and poor IgE antibody production to larval ES antigen in T. canis infected SJL mice, were investigated using F1 hybrid and back-cross mice. The former was regulated by more than one gene, while the latter was a recessive trait. The degree of eosinophilia after infection showed no relationship with the total numbers of larvae recovered from T. canis infected inbred mice.
为了阐明寄生虫感染中嗜酸性粒细胞增多与IgE抗体产生之间的关系，在8个近交系小鼠感染犬弓首蛔虫后，研究了嗜酸性粒细胞增多的程度以及针对犬弓首蛔虫幼虫ES抗原的IgE抗体水平。SJL小鼠的嗜酸性粒细胞增多程度远高于其他近交系。然而，SJL小鼠中针对幼虫ES抗原的IgE抗体水平在这些近交系中是最低的。同样，AKR小鼠的嗜酸性粒细胞增多程度略高于除SJL小鼠外的其他品系，但AKR小鼠中针对幼虫ES抗原的IgE抗体水平与SJL小鼠一样低。因此，嗜酸性粒细胞增多的高反应者并不总是针对幼虫ES抗原产生IgE抗体的高反应者。利用F1杂交和回交小鼠研究了犬弓首蛔虫感染的SJL小鼠中两个性状的遗传情况，即明显的嗜酸性粒细胞增多和针对幼虫ES抗原的IgE抗体产生不佳。前者受多个基因调控，而后者是隐性性状。感染后嗜酸性粒细胞增多的程度与从感染犬弓首蛔虫的近交系小鼠中回收的幼虫总数无关。
