可溶性致瘤性抑制因子2与ST段抬高型心肌梗死患者左心室血栓形成有关。

Soluble suppression of tumorigenicity 2 associated with left ventricular thrombosis in patients with ST-segment elevation myocardial infarction.

作者信息

Du Xinjia, Kumar Perkash, Liu Chen, Liu Jiahua, Chen Lei, Lu Yuan, Zhang Zhuoqi

机构信息

Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

出版信息

BMC Cardiovasc Disord. 2025 Mar 20;25(1):204. doi: 10.1186/s12872-025-04667-y.

DOI:10.1186/s12872-025-04667-y

PMID:40114062

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11924689/

Abstract

BACKGROUND

Left ventricular thrombosis (LVT) after acute ST-segment elevation myocardial infarction (STEMI) is closely related to inflammation. Soluble Suppression of Tumorigenicity 2 (sST2) expressed as a novel inflammatory marker, has received much attention in recent years. However, the relationship between sST2 and LVT is unclear. This study aimed to investigate the correlation between sST2 and LVT formation after emergency PCI (pPCI) in STEMI patients.

METHODS

293 patients with STEMI who were tested for sST2 at admission within 24 h at the Affiliated Hospital of Xuzhou Medical University from June 2018 to August 2023 were consecutively enrolled and evaluated for myocardial infarction characteristics and the presence of LVT by cardiac magnetic resonance imaging (CMR). The diagnosis of LVT was defined as a left ventricular cavity in the late gadolinium enhancement (LGE) of CMR with a low signal intensity mass.

RESULTS

A total of 38 patients developed LVT after STEMI, multivariable logistic regression analysis showed that sST2 [P = 0.002, OR = 1.01 (1.01 ~ 1.02)] an independent predictor of LVT formation. The results of the net reclassification index (NRI) and Integrated Discrimination Improvement Index (IDI) suggested that sST2 could improve the conventional model of LVT. A linear relationship between sST2 and LVT was fitted using a restricted cubic spline (RCS).

CONCLUSION

sST2 was independently associated with LVT formation after pPCI in STEMI patients, and sST2 improved the risk modeling of LVT.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

急性ST段抬高型心肌梗死（STEMI）后左心室血栓形成（LVT）与炎症密切相关。可溶性肿瘤抑制因子2（sST2）作为一种新型炎症标志物近年来备受关注。然而，sST2与LVT之间的关系尚不清楚。本研究旨在探讨STEMI患者急诊经皮冠状动脉介入治疗（pPCI）后sST2与LVT形成之间的相关性。

方法

连续纳入2018年6月至2023年8月在徐州医科大学附属医院就诊且在入院24小时内检测sST2的293例STEMI患者，通过心脏磁共振成像（CMR）评估心肌梗死特征及LVT的存在情况。LVT的诊断定义为CMR延迟钆增强（LGE）时左心室腔内低信号强度肿块。

结果

共有38例STEMI患者发生LVT，多变量逻辑回归分析显示sST2[P = 0.002，OR = 1.01（1.01～1.02）]是LVT形成的独立预测因子。净重新分类指数（NRI）和综合判别改善指数（IDI）结果表明，sST2可改善LVT的传统模型。使用受限立方样条（RCS）拟合sST2与LVT之间的线性关系。