Naushad Vamanjore A, Purayil Nishan K, Varikkodan Irfan, Badi Ahmed M, Baghi Mohamed A, Chandra Prem, Alarbi Khaled M S, Althani Maryam K, Aboughalia Ahmed T, Farooqi Amer, Kartha Anand B, Elzouki Abdelnaser
Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Clinical Department, College of Medicine-QU Health, Qatar University, Doha, Qatar.
IJID Reg. 2025 Feb 4;14:100592. doi: 10.1016/j.ijregi.2025.100592. eCollection 2025 Mar.
infection (CDI) is one of the most common causes of diarrhea in healthcare facilities, imposing a significant burden on health-related budgets and resources worldwide. We aimed to study the demographic features, laboratory findings, and outcomes of CDI in Qatar.
A retrospective study involving adult patients with a confirmed diagnosis of CDI was conducted.
Of the 595 patients, 308 (51.8%) were men with a mean age of 58 ± 19.9 years. The median duration of symptoms was 2 days, with an interquartile range values of 2-4 days. The most common symptoms reported were diarrhea (90.6%) and abdominal pain (41.5%). A total of 426 (71.6%) and 422 (70.9%) patients had a history of exposure to antibiotics and proton pump inhibitors, respectively, while 461 (77.7%) patients had a history of contact with a healthcare facility in the prior 3 months. Respiratory tract infections (33.9%) and urinary tract infections (22.4%) were the most common indications for antibiotic use in the study population. Increased C-reactive protein levels were the most frequently observed laboratory findings. Sepsis was identified as the most common complication (10.4 %). Reinfection was observed in 75 (12.6%) patients. Vancomycin monotherapy was the most commonly prescribed treatment.
In Qatar, CDI remains a significant health concern, primarily affecting elderly men, especially those who have had hospital admissions or used proton pump inhibitors or antibiotics. Preventive measures and increased knowledge of contact precautions and hand hygiene, particularly among healthcare workers, will help to reduce transmission. Raising physician awareness regarding the prudent use of antibiotics and antibiotic stewardship will serve as an adjunct to reduce the incidence of CDIs.
艰难梭菌感染（CDI）是医疗机构中腹泻最常见的病因之一，给全球卫生相关预算和资源带来了沉重负担。我们旨在研究卡塔尔CDI的人口统计学特征、实验室检查结果及预后情况。
开展一项回顾性研究，纳入确诊为CDI的成年患者。
595例患者中，308例（51.8%）为男性，平均年龄58±19.9岁。症状的中位持续时间为2天，四分位间距值为2 - 4天。报告的最常见症状为腹泻（90.6%）和腹痛（41.5%）。分别有426例（71.6%）和422例（70.9%）患者有抗生素和质子泵抑制剂暴露史，而461例（77.7%）患者在之前3个月内有医疗机构接触史。呼吸道感染（33.9%）和尿路感染（22.4%）是研究人群中最常见的抗生素使用指征。C反应蛋白水平升高是最常观察到的实验室检查结果。脓毒症被确定为最常见的并发症（10.4%）。75例（12.6%）患者出现再次感染。万古霉素单药治疗是最常用的治疗方法。
在卡塔尔，CDI仍然是一个重大的健康问题，主要影响老年男性，尤其是那些有住院史或使用过质子泵抑制剂或抗生素的患者。预防措施以及加强对接触预防措施和手卫生的认识，尤其是在医护人员中，将有助于减少传播。提高医生对谨慎使用抗生素和抗生素管理的认识将有助于降低CDI的发病率。
