乙型肝炎核心相关抗原即时检测作为治疗资格风险分层工具：来自肯尼亚的经验。
Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.
作者信息
Downs Louise O, Okanda Dorcas, Chirro Oscar, Zaharani Mwanakombo, Safari Benson, Aliyan Nadia, Andersson Monique I, Tanaka Yasuhito, Etyang Anthony O, Shimakawa Yusuke, Githinji George, Matthews Philippa C
机构信息
Nuffield Department of Medicine, University of Oxford, Oxford, UK.
KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
出版信息
Open Forum Infect Dis. 2025 Mar 6;12(3):ofaf125. doi: 10.1093/ofid/ofaf125. eCollection 2025 Mar.
Abstract
We undertook a point-of-care test for hepatitis B core-related antigen in adults with hepatitis B virus in Kilifi, Kenya. A positive test identified all individuals with a hepatitis B viral load >200 000 IU/mL and who were hepatitis B e antigen positive. It also correlated with a higher alanine aminotransferase (ALT) level ( = .03), raised aspartate transaminase-to-platelet ratio index (APRI) ( < .001), and higher elastography scores ( = .03).
摘要
我们在肯尼亚基利菲对感染乙型肝炎病毒的成年人进行了乙型肝炎核心相关抗原即时检验。检测呈阳性可识别出所有乙型肝炎病毒载量>200 000 IU/mL且乙型肝炎e抗原呈阳性的个体。它还与较高的丙氨酸转氨酶（ALT）水平（P = 0.03）、升高的天冬氨酸转氨酶与血小板比值指数（APRI）（P < 0.001）以及较高的弹性成像评分（P = 0.03）相关。
相似文献
1
Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.乙型肝炎核心相关抗原即时检测作为治疗资格风险分层工具：来自肯尼亚的经验。
Open Forum Infect Dis. 2025 Mar 6;12(3):ofaf125. doi: 10.1093/ofid/ofaf125. eCollection 2025 Mar.
2
STRIKE-HBV: establishing an HBV screening programme in Kilifi, Kenya-challenges, successes and lessons learnt.STRIKE-HBV：在肯尼亚基利菲建立乙肝病毒筛查项目——挑战、成功与经验教训。
Sex Transm Infect. 2024 Jul 26;100(5):325-328. doi: 10.1136/sextrans-2024-056163.
3
Transient elastography, APRI, and ultrasound have minimal utility in chronic low-replicative hepatitis B infection.瞬时弹性成像、APRI（天冬氨酸氨基转移酶与血小板比值指数）和超声在慢性低复制型乙型肝炎感染中的应用价值极小。
Eur J Gastroenterol Hepatol. 2014 Sep;26(9):1010-4. doi: 10.1097/MEG.0000000000000165.
4
Non-linear association between liver fibrosis scores and viral load in patients with chronic hepatitis B.慢性乙型肝炎患者肝纤维化评分与病毒载量之间的非线性关系。
Clin Mol Hepatol. 2024 Oct;30(4):793-806. doi: 10.3350/cmh.2024.0252. Epub 2024 Jul 19.
5
Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa.基于 HBeAg 和 ALT 建立简单评分系统，用于选择非洲乙型肝炎病毒治疗患者。
J Hepatol. 2018 Oct;69(4):776-784. doi: 10.1016/j.jhep.2018.05.024. Epub 2018 Jul 1.
6
Simplifying Treatment Criteria in Chronic Hepatitis B: Reducing Barriers to Elimination.简化慢性乙型肝炎治疗标准：消除消除障碍。
Clin Infect Dis. 2023 Feb 8;76(3):e791-e800. doi: 10.1093/cid/ciac385.
7
Diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index and liver stiffness measurement in hepatitis B virus-infected patients with persistently normal alanine aminotransferase.在丙型肝炎病毒感染持续正常丙氨酸氨基转移酶患者中，FIB-4、天门冬氨酸氨基转移酶与血小板比值指数和肝硬度测量的诊断价值。
World J Gastroenterol. 2017 Aug 21;23(31):5746-5754. doi: 10.3748/wjg.v23.i31.5746.
8
Validation of a novel point-of-care test for alanine aminotransferase measurement: A pilot cohort study.用于丙氨酸氨基转移酶测量的新型即时检验的验证：一项试点队列研究。
Liver Int. 2023 May;43(5):989-999. doi: 10.1111/liv.15531. Epub 2023 Feb 16.
9
Decreasing hepatitis B viral load is associated with a risk of significant liver fibrosis in hepatitis B e antigen positive chronic hepatitis B.乙肝 e 抗原阳性慢性乙型肝炎患者乙肝病毒载量下降与显著肝纤维化风险相关。
J Med Virol. 2014 Nov;86(11):1828-37. doi: 10.1002/jmv.24000. Epub 2014 Aug 21.
10
Accuracy of international guidelines for identifying significant fibrosis in hepatitis B e antigen--negative patients with chronic hepatitis.国际指南识别乙型肝炎 e 抗原阴性慢性乙型肝炎患者显著纤维化的准确性。
Clin Gastroenterol Hepatol. 2013 Nov;11(11):1493-1499.e2. doi: 10.1016/j.cgh.2013.05.038. Epub 2013 Jun 28.
本文引用的文献
1
STRIKE-HBV: establishing an HBV screening programme in Kilifi, Kenya-challenges, successes and lessons learnt.STRIKE-HBV：在肯尼亚基利菲建立乙肝病毒筛查项目——挑战、成功与经验教训。
Sex Transm Infect. 2024 Jul 26;100(5):325-328. doi: 10.1136/sextrans-2024-056163.
2
Costs of integrating hepatitis B screening and antiviral prophylaxis into routine antenatal care in Burkina Faso: Treat all versus targeted strategies.将乙型肝炎病毒筛查和抗病毒预防纳入布基纳法索常规产前护理的成本：全面治疗与目标治疗策略。
Int J Gynaecol Obstet. 2024 Jul;166(1):44-61. doi: 10.1002/ijgo.15515. Epub 2024 Apr 3.
3
Impact and cost-effectiveness of hepatitis B virus prophylaxis in pregnancy: a dynamic simulation modelling study.乙型肝炎病毒预防在妊娠中的影响和成本效益：一项动态模拟建模研究。
Lancet Gastroenterol Hepatol. 2023 Jul;8(7):635-645. doi: 10.1016/S2468-1253(23)00074-2. Epub 2023 May 5.
4
Rapid Point-of-Care Test for Hepatitis B Core-Related Antigen to Diagnose High Viral Load in Resource-Limited Settings.用于诊断资源有限环境中高病毒载量的乙型肝炎核心相关抗原即时检测
Clin Gastroenterol Hepatol. 2023 Jul;21(7):1943-1946.e2. doi: 10.1016/j.cgh.2022.05.026. Epub 2022 Jun 11.
5
Point-of-care HIV viral load testing combined with task shifting to improve treatment outcomes (STREAM): findings from an open-label, non-inferiority, randomised controlled trial.即时检测 HIV 病毒载量联合工作任务转换以改善治疗结局（STREAM）：一项开放标签、非劣效性、随机对照试验的结果。
Lancet HIV. 2020 Apr;7(4):e229-e237. doi: 10.1016/S2352-3018(19)30402-3. Epub 2020 Feb 24.
6
Evaluation of Rapid Diagnostic Tests for Assessment of Hepatitis B in Resource-Limited Settings.在资源有限的环境中评估乙型肝炎快速诊断检测的效果。
Ann Glob Health. 2019 Jul 4;85(1):98. doi: 10.5334/aogh.2562.
7
Hepatitis B Core-related Antigen: An Alternative to Hepatitis B Virus DNA to Assess Treatment Eligibility in Africa.乙型肝炎核心相关抗原：评估非洲治疗资格的替代乙型肝炎病毒 DNA。
Clin Infect Dis. 2020 Mar 17;70(7):1442-1452. doi: 10.1093/cid/ciz412.
8
Poor Sensitivity of Commercial Rapid Diagnostic Tests for Hepatitis B e Antigen in Senegal, West Africa.西非塞内加尔商业乙型肝炎 e 抗原快速诊断检测的敏感性较差。
Am J Trop Med Hyg. 2018 Aug;99(2):428-434. doi: 10.4269/ajtmh.18-0116. Epub 2018 May 31.
9
Hepatitis C in sub-Saharan Africa: the current status and recommendations for achieving elimination by 2030.撒哈拉以南非洲的丙型肝炎：现状及 2030 年消除目标的建议。
Lancet Gastroenterol Hepatol. 2017 Dec;2(12):910-919. doi: 10.1016/S2468-1253(17)30249-2.
10
Review article: hepatitis B core-related antigen (HBcrAg): an emerging marker for chronic hepatitis B virus infection.综述文章：乙型肝炎核心相关抗原（HBcrAg）：慢性乙型肝炎病毒感染的新兴标志物。
Aliment Pharmacol Ther. 2018 Jan;47(1):43-54. doi: 10.1111/apt.14376. Epub 2017 Oct 16.
Zotero 插件