醛固酮持续输注：体重增加的相关因素。

Continuous infusion of aldosterone: correlates of body weight gain.

作者信息

Devenport L D, Goodwin K G, Hopkins P M

出版信息

Pharmacol Biochem Behav. 1985 May;22(5):707-9. doi: 10.1016/0091-3057(85)90517-9.

Abstract

Aldosterone stimulated body weight gain in adrenalectomized male rats across all but the highest of seven doses delivered by continuous infusion. Gains were especially strong in the latter part of the 12-day infusion period peaking at values twice those of adrenalectomized rats given only glucocorticoid replacement or sham infusions. The gains were not related to skeletal growth, and hematocrit and percent tissue water were only modestly and inversely related to weight gain (rs = -.24). In contrast, epididymal fat pad mass correlated strongly (r = .72), indicating that the gains were partly or wholly attributal to adipose tissue hypertrophy.

摘要

通过持续输注给予肾上腺切除的雄性大鼠七剂醛固酮，除了最高剂量外，其他剂量均能刺激体重增加。在为期12天的输注期后期，体重增加尤为明显，峰值是仅接受糖皮质激素替代或假输注的肾上腺切除大鼠的两倍。体重增加与骨骼生长无关，血细胞比容和组织水百分比仅与体重增加呈适度负相关（rs = -0.24）。相比之下，附睾脂肪垫质量与之密切相关（r = 0.72），表明体重增加部分或全部归因于脂肪组织肥大。