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The hypotensive effect of intracarotid injections of adenosine triphosphate depends on its hydrolysis to adenosine.

作者信息

Ribeiro J A, Lima M S

出版信息

Pharmacol Res Commun. 1985 Mar;17(3):255-60. doi: 10.1016/0031-6989(85)90100-6.

DOI:10.1016/0031-6989(85)90100-6
PMID:4011648
Abstract

The effects of intra-carotid injections of adenosine, adenosine triphosphate (ATP) and alpha-beta-methylene ATP were studied on arterial blood pressure of anaesthetized cats. Adenosine and ATP decreased arterial blood pressure, whilst the ATP stable analogue, alpha-beta-methylene ATP caused a dose-dependent increase in arterial blood pressure. These results suggest that the hypotensive action of ATP might depend on its previous hydrolysis into adenosine.

摘要

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