Sun M K, Wahlestedt C, Reis D J
Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021.
Eur J Pharmacol. 1992 Nov 24;224(1):93-6. doi: 10.1016/0014-2999(92)94824-f.
In anesthetized rats, iontophoretic application of ATP excited the spinal cord-projection neurons in the rostral ventrolateral reticular nucleus of the medulla oblongata. The neuronal response to ATP was mimicked and then blocked by alpha,beta-methylene-ATP, a metabolically stable ATP analogue, and the response was abolished by suramin. Microinjections of ATP (3-100 pmol) into the rostral ventrolateral medulla produced a powerful pressor response. The results suggest that ATP may function as a neurotransmitter or neuromodulator involved in medullary regulation of cardiovascular functions.
在麻醉大鼠中，通过离子电渗法施加ATP可兴奋延髓头端腹外侧网状核中的脊髓投射神经元。α,β-亚甲基ATP（一种代谢稳定的ATP类似物）模拟并随后阻断了神经元对ATP的反应，而苏拉明则消除了该反应。向延髓头端腹外侧微量注射ATP（3 - 100皮摩尔）可产生强烈的升压反应。结果表明，ATP可能作为一种神经递质或神经调质参与心血管功能的延髓调节。
