Şam Emre, Söğütdelen Emrullah, Akkaş Fatih, Şeker Kamil Gökhan, Özlü Deniz Noyan, Güner Ekrem
Department of Urology, University of Health Sciences, Erzurum City Hospital, Erzurum, Turkey.
Department of Urology, Bolu Abant Izzet Baysal Training and Research Hospital, Bolu Abant Izzet Baysal University, Bolu, Turkey.
Can Urol Assoc J. 2025 Jul;19(7):E246-E250. doi: 10.5489/cuaj.8999.
This study examined whether there is a relationship between vitamin D levels and post-prostatectomy incontinence (PPI).
We included patients from our tertiary center who underwent robotic radical prostatectomy (RP) and had their serum vitamin D levels assessed no more than three months before the procedure. Continence status was recorded at one, three, six, and 12 months postoperatively. Urinary continence was defined as either no urine leak or using a pad to feel secure against potential minimal leakage. Patients were divided into groups according to continence status at the 12 postoperative month (group 1: continent patients; group 2: PPI patients). Groups were compared in terms of patient characteristics, previously known PPI risk factors, and serum vitamin D levels.
The entire study cohort consisted of 318 patients. The rate of PPI was 14.5%. Since the mean age, body mass index, and prostate volume were significantly higher in group 2 than in group 1, propensity score matching was applied. Before and after propensity score matching, serum vitamin D levels were higher in group 1 than in group 2 at the 12 postoperative month, but no statistically significant difference was observed; however, after propensity score matching, serum vitamin D levels were significantly higher in continent patients than in incontinent patients at one, three, and six months postoperatively.
Serum vitamin D may be an essential marker in regaining continence in the early period after RP.
本研究探讨了维生素D水平与前列腺切除术后尿失禁（PPI）之间是否存在关联。
我们纳入了来自三级中心的患者，这些患者接受了机器人根治性前列腺切除术（RP），并在手术前不超过三个月评估了血清维生素D水平。在术后1个月、3个月、6个月和12个月记录控尿状态。尿失禁定义为无尿液漏出或使用尿垫以防潜在的微量漏尿。根据术后12个月的控尿状态将患者分为两组（第1组：控尿患者；第2组：PPI患者）。比较两组患者的特征、既往已知的PPI危险因素和血清维生素D水平。
整个研究队列包括318名患者。PPI发生率为14.5%。由于第2组的平均年龄、体重指数和前列腺体积显著高于第1组，因此应用了倾向评分匹配。倾向评分匹配前后，术后12个月时第1组的血清维生素D水平高于第2组，但未观察到统计学显著差异；然而，倾向评分匹配后，术后1个月、3个月和6个月时，控尿患者的血清维生素D水平显著高于尿失禁患者。
血清维生素D可能是RP术后早期恢复控尿的重要标志物。
