Stephens D B
Q J Exp Physiol. 1985 Jan;70(1):129-35. doi: 10.1113/expphysiol.1985.sp002884.
Young growing pigs which had been trained to press a panel in order to obtain small deliveries of food and adapted to eating all their food in one meal per day were surgically fitted with an exteriorized cannula connected to the duodenum. An infusion of 250 ml 15% (w/v) glucose solution 10 min before the meal did not influence meal size, whereas a similar infusion shortly after beginning a meal significantly reduced meal size. When the membrane transport and metabolism of glucose was reduced by infusing the antimetabolite, 2-deoxy-D-glucose, before the glucose infusion, the suppression of appetite was attenuated. Intrathoracic truncal vagotomy abolished the effects of intraduodenal glucose. The possibility that a receptor sensitive to transport and metabolism of glucose exists in the duodenum is discussed.
对经过训练会按压面板以获取少量食物供应且已适应每天一餐吃完所有食物的幼龄生长猪进行手术，安装与十二指肠相连的外置套管。在进食前10分钟输注250毫升15%（重量/体积）的葡萄糖溶液对进食量没有影响，而在开始进食后不久进行类似输注则显著减少进食量。在输注葡萄糖前输注抗代谢物2-脱氧-D-葡萄糖以降低葡萄糖的膜转运和代谢时，食欲抑制作用减弱。胸段迷走神经切断术消除了十二指肠内葡萄糖的作用。文中讨论了十二指肠中存在对葡萄糖转运和代谢敏感的受体的可能性。
