Fowden A L, Comline R S, Silver M
Q J Exp Physiol. 1985 Jan;70(1):23-35. doi: 10.1113/expphysiol.1985.sp002894.
The effect of exogenous cortisol on glycogen deposition in a number of fetal tissues was investigated in chronically catheterized fetal pigs between 80 and 95 d of gestation (term 114 d). Intravascular infusion of cortisol for 48 h increased the fetal plasma concentration of cortisol 4-fold to a value similar to that observed in piglets near to term. After infusion of cortisol, the concentration of glycogen in the lung was lower while the levels in skeletal muscle and liver were higher than those found in unoperated fetuses. There were no detectable changes in either skin or cardiac muscle glycogen after cortisol infusion. High endogenous cortisol concentrations were observed in some of the catheterized control fetuses and in two unoperated fetuses adjacent to the site of cortisol infusion. These fetuses also had detectable changes in lung, liver and skeletal muscle glycogen. When the data from all the fetuses, whether infused, control catheterized or unoperated, were combined there was a significant positive correlation between both liver and skeletal muscle glycogen concentrations and log plasma cortisol (r = 0.70 and 0.72 respectively, P less than 0.01). Lung glycogen levels were inversely related to log plasma cortisol (r = -0.67, P less than 0.01). No relation between either cardiac or skin glycogen concentration and fetal plasma cortisol could be detected. These observations demonstrate that cortisol has a marked effect on tissue glycogen levels in the immature fetal pig and suggest that the changes in glycogen concentrations observed in the liver, lung and skeletal muscle before term may be due to the pre-partum surge in fetal cortisol.
在妊娠80至95天（足月为114天）的慢性插管胎儿猪中，研究了外源性皮质醇对多个胎儿组织中糖原沉积的影响。血管内输注皮质醇48小时，使胎儿血浆皮质醇浓度增加了4倍，达到与接近足月的仔猪中观察到的值相似的水平。输注皮质醇后，肺中糖原浓度降低，而骨骼肌和肝脏中的糖原水平高于未手术的胎儿。输注皮质醇后，皮肤或心肌糖原没有可检测到的变化。在一些插管对照胎儿以及与皮质醇输注部位相邻的两个未手术胎儿中观察到高内源性皮质醇浓度。这些胎儿在肺、肝脏和骨骼肌糖原中也有可检测到的变化。当将所有胎儿的数据（无论是输注、对照插管还是未手术的）合并时，肝脏和骨骼肌糖原浓度与血浆皮质醇对数之间均存在显著正相关（分别为r = 0.70和0.72，P < 0.01）。肺糖原水平与血浆皮质醇对数呈负相关（r = -0.67，P < 0.01）。未检测到心肌或皮肤糖原浓度与胎儿血浆皮质醇之间的关系。这些观察结果表明，皮质醇对未成熟胎儿猪的组织糖原水平有显著影响，并表明足月前在肝脏、肺和骨骼肌中观察到的糖原浓度变化可能是由于胎儿皮质醇在产前的激增。
