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人类和各种动物物种的血液流变学。

The blood rheology of man and various animal species.

作者信息

Amin T M, Sirs J A

出版信息

Q J Exp Physiol. 1985 Jan;70(1):37-49. doi: 10.1113/expphysiol.1985.sp002895.

DOI:10.1113/expphysiol.1985.sp002895
PMID:4011828
Abstract

A comparative study has been made of the blood rheology, and its component factors, in horse, sheep, cattle, goat, camel, pig, dog, rabbit and man. The erythrocyte flexibility of horse red cells is high relative to man, that of pig, dog, camel and rabbit comparable, but less flexible, and sheep, cattle and goat relatively inflexible. The erythrocyte flexibility of horse, sheep, cattle and goats does not vary with the plasma fibrinogen level, as occurs with human and rabbit cells. Washing erythrocytes and then suspending them in isotonic saline makes the erythrocytes of all species relatively inflexible. There is a factor in horse plasma, which is not fibrinogen, that makes horse and human erythrocytes suspended in it very flexible. The blood viscosity of all species is comparable at high shear rates (230 s-1) due to the shape of the cells compensating for their flexibility. The variations of blood viscosity at low shear rates (11.5 s-1) were also found to depend on the erythrocyte flexibility, and only influenced indirectly by the fibrinogen concentration. There is no significant effect of temperature on the erythrocyte flexibility of horse, sheep, cattle, goat and a small number of human subjects. This is reflected in the way the viscosity of these bloods varies with temperature.

摘要

对马、羊、牛、山羊、骆驼、猪、狗、兔子和人类的血液流变学及其组成因素进行了比较研究。马红细胞的红细胞柔韧性相对于人类较高,猪、狗、骆驼和兔子的红细胞柔韧性相当,但柔韧性较差,而绵羊、牛和山羊的红细胞柔韧性相对较差。马、绵羊、牛和山羊的红细胞柔韧性不会随血浆纤维蛋白原水平而变化,而人类和兔子的细胞则会。洗涤红细胞然后将它们悬浮在等渗盐水中会使所有物种的红细胞相对缺乏柔韧性。马血浆中有一种不是纤维蛋白原的因子,它会使悬浮在其中的马和人类红细胞非常柔韧。由于细胞形状补偿了它们的柔韧性,所有物种在高剪切速率(230 s-1)下的血液粘度相当。还发现低剪切速率(11.5 s-1)下血液粘度的变化取决于红细胞柔韧性,并且仅间接受纤维蛋白原浓度影响。温度对马、绵羊、牛、山羊和少数人类受试者的红细胞柔韧性没有显著影响。这反映在这些血液的粘度随温度变化的方式上。

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