Triple synergistic enhancement of breast cancer treatment via chemotherapy, chemodynamic therapy, and tumor starvation therapy driven by lipid-COF nanoparticles.

In this study, a novel cascade nano delivery system, Cur/Gox@LCOF, was developed for enhanced breast cancer therapy. The system loads curcumin (Cur) and glucose oxidase (Gox) into a lipid copper-based organic framework (LCOF) carrier for enhanced tumor therapy. The nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), and dynamic light scattering (DLS), which showed that they had a uniform spherical morphology with an average particle size of about 80 nm, displaying stable colloidal properties. The system showed excellent stability under simulated physiological conditions and exhibited pH-responsive drug release properties, contributing to the controlled release of Cur and Gox. The results of in vitro cellular experiments showed that Cur/Gox@LCOF significantly enhanced the production of reactive oxygen species (ROS), leading to significant cytotoxicity in cancer cells. In addition, the system also demonstrated enhanced therapeutic efficacy and good biocompatibility in a tumor mouse model. Thus, this study developed a nanocarrier platform for triple synergistic chemokinetic/chemotherapy/starvation therapy, which has promising applications in the efficient treatment of tumors.