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姜黄素载药固体脂质纳米粒增强乳腺癌的抗癌效率。

Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.

机构信息

Department of Biotechnology, Bengbu Medical College, Bengbu 233030, China.

AnHui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu 233030, China.

出版信息

Molecules. 2018 Jun 29;23(7):1578. doi: 10.3390/molecules23071578.

DOI:10.3390/molecules23071578
PMID:29966245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6099699/
Abstract

Curcumin (Cur) has been widely used in medicine, due to its antibacterial, anti-inflammatory, antioxidant, and antitumor effects. However, its clinic application is limited by its instability and poor solubility. In the present wok, curcumin was loaded into solid lipid nanoparticles (SLNs), in order to improve the therapeutic efficacy for breast cancer. The results measured using transmission electron microscopy (TEM) indicated that Cur-SLNs have a well-defined spherical shape; the size was about 40 nm with a negative surface charge. The drug loading and encapsulation efficiency in SLNs reached 23.38% and 72.47%, respectively. The Cur-SLNs showed a stronger cytotoxicity against SKBR3 cells. In vitro cellular uptake study demonstrated a high uptake efficiency of the Cur-SLNs by SKBR3 cells. Moreover, Cur-SLNs induced higher apoptosis in SKBR3 cells, compared to cells treated by free drug. In addition, Western blot analysis revealed that Cur-SLNs could promote the ratio of , but decreased the expression of and . These results suggested that Cur-SLNs could be a potential useful chemotherapeutic formulation for breast cancer therapy.

摘要

姜黄素（Cur）由于其具有抗菌、抗炎、抗氧化和抗肿瘤作用，已被广泛应用于医学领域。然而，其临床应用受到其不稳定性和较差的溶解度的限制。在本研究中，将姜黄素载入固体脂质纳米粒（SLNs）中，以提高乳腺癌的治疗效果。透射电子显微镜（TEM）测量结果表明，Cur-SLNs 具有明确的球形形状；粒径约为 40nm，带负电荷。载药和包封效率分别达到 23.38%和 72.47%。Cur-SLNs 对 SKBR3 细胞的细胞毒性更强。体外细胞摄取研究表明，Cur-SLNs 被 SKBR3 细胞的摄取效率很高。此外，Cur-SLNs 诱导 SKBR3 细胞凋亡的作用高于游离药物处理的细胞。此外，Western blot 分析表明，Cur-SLNs 可以促进 的比值，但降低 和 的表达。这些结果表明，Cur-SLNs 可能是治疗乳腺癌的一种有潜力的化疗制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/4cb82367bf9b/molecules-23-01578-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/37e53456b9c3/molecules-23-01578-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/f9c6f1093a45/molecules-23-01578-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/4cb82367bf9b/molecules-23-01578-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/d99bf7696065/molecules-23-01578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/6216070029b4/molecules-23-01578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/795899407bbe/molecules-23-01578-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/c84b448677eb/molecules-23-01578-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/a5b0ae318e53/molecules-23-01578-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a57/6099699/37e53456b9c3/molecules-23-01578-g006.jpg
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