Cao Xiangrong, Duan Yanru, Hao Yibo, Wang Zhe, Zheng Chenhai, Zhang Zhiming, Qin Jie, Wu Dahai
Postgraduate Training Base of Dalian Medical University in the General Hospital of Northern Theater Command, Dalian, Liaoning, 116044, China.
Department of Otolaryngology, General Hospital of Northern Theater Command, No.83, Wenhua Road, Shenhe District, Shenyang, Liaoning, 110016, China.
Eur Arch Otorhinolaryngol. 2025 May;282(5):2731-2737. doi: 10.1007/s00405-025-09320-0. Epub 2025 Mar 21.
To research the correlation between abdominal visceral fat and laryngopharyngeal reflux (LPR) in patients with obstructive sleep apnea (OSA).
This study included 72 OSA patients, and the correlation between abdominal visceral fat and the severity of LPR was analyzed after abdominal visceral fat area (VFA) was measured according to body composition analysis and reflux symptom index (RSI) score was completed. Finally, in order to further clarify the effect of VFA on LPR, multiple linear regression analysis was performed on the collected related parameters.
Partial correlation analysis showed that the VFA was positively correlated with the RSI score (r = 0.502, p < 0.001) after controlling for apnea-hypopnea index (AHI), body mass index (BMI), lowest oxygen saturation (LSO₂), age, and sex. The multiple linear regression analysis indicated that VFA and AHI were the factors influencing LPR (t = 4.678, p < 0.001; t = 3.164, p = 0.002).
Our study found that VFA was associated with RSI score in OSA patients, but BMI didn't show an independent correlation with RSI score. This indicated that we should pay attention to the effect of abdominal visceral fat on LPR in OSA patients, and more experiments are needed in the future to clarify the relationship between the two.
研究阻塞性睡眠呼吸暂停（OSA）患者腹部内脏脂肪与喉咽反流（LPR）之间的相关性。
本研究纳入72例OSA患者，根据身体成分分析测量腹部内脏脂肪面积（VFA）并完成反流症状指数（RSI）评分后，分析腹部内脏脂肪与LPR严重程度之间的相关性。最后，为进一步阐明VFA对LPR的影响，对收集的相关参数进行多元线性回归分析。
偏相关分析显示，在控制呼吸暂停低通气指数（AHI）、体重指数（BMI）、最低血氧饱和度（LSO₂）、年龄和性别后，VFA与RSI评分呈正相关（r = 0.502，p < 0.001）。多元线性回归分析表明，VFA和AHI是影响LPR的因素（t = 4.678，p < 0.001；t = 3.164，p = 0.002）。
我们的研究发现，OSA患者的VFA与RSI评分相关，但BMI与RSI评分未显示出独立相关性。这表明我们应关注OSA患者腹部内脏脂肪对LPR的影响，未来还需要更多实验来阐明两者之间的关系。
