Wenyan Huang, Yang Hao, Huifen Qiao, Hua Yang, Ning Zhang, Changjun Teng, Hui Ma
The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
BMC Psychiatry. 2025 Mar 21;25(1):270. doi: 10.1186/s12888-025-06694-7.
Major depressive disorder (MDD) imposes serious effect on patient's psychosocial function, which hinders the full recovery from the disease and increases the risk of recurrence, although the participants had achieved clinical remission. To understand the relationship between psychosocial function and depressive symptoms could facilitate recurrence prevention. Therefore, the purpose of this study was to analyze the relation among psychosocial function and BDI score in Chinese patients with clinically cured depression within 1 year follow-up.
One hundred nineteen valid participants were assessed at baseline(t1), months 6(t2) and months 12(t3). Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms and indicate the possibility of depression level. Generic Quality of Life Inventory (GQOLI) was used to assessed the participants' psychosocial function(F), including body function (BF), psychological function (PF) and social function (SF). The application of a cross-lagged panel model (CLPM) approach revealed an association between BDI and psychosocial function.
The CLPM results showed total average score of psychosocial function have reciprocal influence on BDI score. The model analyzed by structural equation modeling satisfied all indices of goodness-of-fit (chi-square = 10.306, TLI = 0.959, CFI = 0.988 RMSEA = 0.115). And body function, psychological function, social function and BDI score also affect each other. Depressive symptoms and psychosocial function could predict scores of each other 6 months later. By comparing standardized cross-lagged path, only social function has a more pronounced impact on depressive symptoms, since the absolute effect of SFt1 → BDIt2 is larger than that of BDIt1 → SFt2 (a1 vs. b1 = -.267, SE = .108, P < 0.05, 95%CI[-.485,-.063]) and the absolute effect of SFt2 → BDIt3 is larger than that of BDIt2 → SFt3 (a2 vs. b2 = -.317, SE = .096, P < 0.01,95%CI[-.508,-.129]).
The current study showed a significant bidirectional association between depressive level and psychosocial function, and the social function exerted more effect on the depression.
尽管参与者已实现临床缓解，但重度抑郁症（MDD）对患者的心理社会功能仍有严重影响，这阻碍了疾病的完全康复并增加了复发风险。了解心理社会功能与抑郁症状之间的关系有助于预防复发。因此，本研究的目的是分析1年内临床治愈的中国抑郁症患者心理社会功能与贝克抑郁量表（BDI）评分之间的关系。
119名有效参与者在基线（t1）、6个月（t2）和12个月（t3）时接受评估。使用贝克抑郁量表第二版（BDI-II）评估抑郁症状并表明抑郁水平的可能性。使用一般生活质量量表（GQOLI）评估参与者的心理社会功能（F），包括身体功能（BF）、心理功能（PF）和社会功能（SF）。采用交叉滞后面板模型（CLPM）方法揭示了BDI与心理社会功能之间的关联。
CLPM结果显示，心理社会功能的总平均分对BDI评分有相互影响。通过结构方程模型分析的模型满足所有拟合优度指标（卡方=10.306，TLI=0.959，CFI=0.988，RMSEA=0.115）。身体功能、心理功能、社会功能和BDI评分也相互影响。抑郁症状和心理社会功能可以预测6个月后的彼此评分。通过比较标准化交叉滞后路径，只有社会功能对抑郁症状有更明显的影响，因为SFt1→BDIt2的绝对效应大于BDIt1→SFt2（a1对b1=-0.267，SE=0.108，P<0.05，95%CI[-0.485，-0.063]），且SFt2→BDIt3的绝对效应大于BDIt2→SFt3（a2对b2=-0.317，SE=0.096，P<0.01，95%CI[-0.508，-0.129]）。
当前研究表明抑郁水平与心理社会功能之间存在显著的双向关联，且社会功能对抑郁症的影响更大。
